Protein Alignment Mct1 and SLC16A14

DIOPT Version :10

• Sequence 1: NP_477334.2
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_689740.2
• Gene: SLC16A14 / 151473
• HGNCID: 26417
• Length: 510
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 175/621 - (28%)
• Similarity: 271/621 - (43%)
• Gaps: 140/621 - (22%)

  Fly    15 HEACEMDMERQPTPP---------DGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGK 70
            ||....|.|..|...         ||||.|::|..||.:||:..|...:.|:...|:|:.|::.:
Human     5 HEDIGYDFEDGPKDKKTLKPHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSR 69

  Fly    71 GYTAWIASIMVGVTFSSGPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGT 135
            |.|||::|:.:|:|...||....|:|..|||...|.|.::.:...::|.:|.||..|.||.|...
Human    70 GLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAA 134

  Fly   136 GLGFGLIYLPAIVSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIV 200
            |||.|:.||||:|.|.:||:.:|:||.|::..|:|||||:...|.::|...||||.||||.|.:.
Human   135 GLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVS 199

  Fly   201 LNCIIFGAMFRPLELEAPPQTPPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRT 265
            ||..:.||:.|||.    |...||.|..                   :.::.||       ...|
Human   200 LNLCVCGALMRPLS----PGKNPNDPGE-------------------KDVRGLP-------AHST 234

  Fly   266 DTAVSGGALCRSNSVGHNLKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLT 330
            ::..|.|...|:......|             |...||                   |..|.|..
Human   235 ESVKSTGQQGRTEEKDGGL-------------GNEETL-------------------CDLQAQEC 267

  Fly   331 PLRDAHRERSASGTMYRPDALYQGSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQ 395
            |.:..||                                 ::|....::|....|
Human   268 PDQAGHR---------------------------------KNMCALRILKTVSWL---------- 289

  Fly   396 EEAKCCGCITCSKETRDTFAEMMN-----FSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAET 455
                       :...|..|.:..:     .||..:.:||.|..........|.:|::::......
Human   290 -----------TMRVRKGFEDWYSGYFGTASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNL 343

  Fly   456 LKLT-KTDASYLISTIGVANTVGRIILGYISDKPWVNRLLVYNVCLTA---CGVSTAMVPLCHDF 516
            ..|: :.|...|.|.|.:.:..|::|||.|:|.|.::   |:||.|.|   ..:|..::||.|.:
Human   344 YNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCIS---VWNVFLLANFTLVLSIFILPLMHTY 405

  Fly   517 QSLAFYCCVFGFTIGAYVGLTSVILVDLLGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDS 581
            ..||..|.:.||:.| |..|..|:..||:|::.|.||:|:::...||::.:|||..||:||:|..
Human   406 AGLAVICALIGFSSG-YFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQK 469

  Fly   582 YAPAFLMAGLMIAISGLVMFAIPPLQRLQVRKSERK 617
            |..:|.:.||:..| |::...|.|..|: :.:|.||
Human   470 YDFSFYICGLLYMI-GILFLLIQPCIRI-IEQSRRK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_477334.2	MFS_MCT_SLC16	34..604	CDD:340910	160/578 (28%)
SLC16A14	NP_689740.2	MFS_MCT14	33..492	CDD:340987	161/579 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..255		11/79 (14%)