DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmd3 and NMD3

DIOPT Version :9

Sequence 1:	NP_477332.1	Gene:	Nmd3 / 31195	FlyBaseID:	FBgn0023542	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_012040.1	Gene:	NMD3 / 856575	SGDID:	S000001213	Length:	518	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	234/516 - (45%)
Similarity:	326/516 - (63%)	Gaps:	39/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AVILCCECGVAIQPNPA-NMCVTCLRNHVDITENIPKQAVLHFCRNCERYLQPPNEWIQAALESR 86
            |.:|||.||..|..:.. .||..|::..||||:.||::|.:.|||||||:||||.:||:|.||||
Yeast    15 ATLLCCNCGTPIDGSTGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPPGQWIRAELESR 79

  Fly    87 ELLAICLKKLKGLKEVKLVDAGFIWTEQHSKRIKVKLTVHGEIIGGTMLQQVFVVEFTVQNQMCN 151
            |||||||::||||.:|:||||.|||||.||:||::||||.||.:..|::||.|.||:.|....|.
Yeast    80 ELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTIIQQTFEVEYIVIAMQCP 144

  Fly   152 DCHRTEAKDFWRCLVQVRQRAENKKTFYYLEQLILKHKAHENTLGIKPEHGGLDFFYANDNHARR 216
            ||.|:...:.||..||:||:..:|:||.:||||||||.||.:|:.|.....|||||||..|||.:
Yeast   145 DCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTISISEAKDGLDFFYAQKNHAVK 209

  Fly   217 MVDFLLTMVPGKVTTSKRLISHDIHSNNYNYKYNWSVEIAPVSKDSAVCLSKKLRHQLGNLSPLV 281
            |:|||..:||.|...|:.|||.|.|:....||:::||||.|:.||..|.|.|||...:||:|..|
Yeast   210 MIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEIVPICKDDLVVLPKKLAKSMGNISQFV 274

  Fly   282 LVNRVSSSIHLIDPLTAQIAELTSQVYFRAPFEAVCNPKQLVEYVVMDIDVIMEKDRKTYPGQGQ 346
            |.:::|:::..:||.|.|.|:|:..||:||||.|:.:..||||::|:|:|       .|...:|
Yeast   275 LCSKISNTVQFMDPTTLQTADLSPSVYWRAPFNALADVTQLVEFIVLDVD-------STGISRG- 331

  Fly   347 VSFKHALCDIWVVRASELGINDNPIHTRSHLGHLLKVGDSVMGYNTGEANINDLEFDKLSSDEIP 411
               ...|.||.|.|.|:||:||...:.|||||.:...|||||||....:|.|...||.|:.|.:|
Yeast   332 ---NRVLADITVARTSDLGVNDQVYYVRSHLGGICHAGDSVMGYFIANSNYNSDLFDGLNIDYVP 393

  Fly   412 DVILVRKHYDRQTRLSQRVWKIKHLAAEATD----------------ERSKYDYHEFLDDLEENE 460
            ||:||:|.|.|:::.| |.||:|.:|.|..|                ||::.||..||.:|||:.
Yeast   394 DVVLVKKLYQRKSKKS-RHWKLKRMAKEHKDIDASLDYNSRAQKQEMERAEKDYELFLQELEEDA 457

  Fly   461 DIRGQVNIYRDTNKTIPIEV----QAAGGDVPQITLEEMLEDMTLECADDEMGEEGGADDT 517
            ::|..||:|::....:|.|.    :....|.|||.::|:|:::      |||..|.|.::|
Yeast   458 ELRQSVNLYKNREANVPPEEHEMDEDEDEDAPQINIDELLDEL------DEMTLEDGVENT 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmd3	NP_477332.1	NMD3	21..390	CDD:224416	183/367 (50%)
Nmd3	NP_477332.1	NMD3	27..255	CDD:282790	123/228 (54%)
NMD3	NP_012040.1	NMD3	11..385	CDD:224416	187/380 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344884
Domainoid	1	1.000	262	1.000	Domainoid score	I305
eggNOG	1	0.900	-	-		E1_COG1499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6127
Inparanoid	1	1.050	446	1.000	Inparanoid score	I253
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53941
OrthoFinder	1	1.000	-	-		FOG0004479
OrthoInspector	1	1.000	-	-		oto100129
orthoMCL	1	0.900	-	-		OOG6_101748
Panther	1	1.100	-	-	LDO	PTHR12746
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R817
SonicParanoid	1	1.000	-	-		X3175
TreeFam	1	0.960	-	-
	15	14.790