DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmd3 and nmd3

DIOPT Version :9

Sequence 1:	NP_477332.1	Gene:	Nmd3 / 31195	FlyBaseID:	FBgn0023542	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_989367.2	Gene:	nmd3 / 394998	XenbaseID:	XB-GENE-942228	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	273/506 - (53%)
Similarity:	355/506 - (70%)	Gaps:	10/506 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GKGAGSNAVILCCECGVAIQPNPANMCVTCLRNHVDITENIPKQAVLHFCRNCERYLQPPNEWIQ 80
            |....|...||||:||:.|.||||||||:|||..|||:|.||||..:|||:.||||||||..|||
Frog     6 GPATSSQGNILCCQCGIPIPPNPANMCVSCLRMQVDISEGIPKQVSVHFCKQCERYLQPPGTWIQ 70

  Fly    81 AALESRELLAICLKKLK-GLKEVKLVDAGFIWTEQHSKRIKVKLTVHGEIIGGTMLQQVFVVEFT 144
            .||||||||.:|||||| .|.:|:|:||||||||.||||:|||||:..|::.|.:|||||||::.
Frog    71 CALESRELLTLCLKKLKANLSKVRLIDAGFIWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYI 135

  Fly   145 VQNQMCNDCHRTEAKDFWRCLVQVRQRAENKKTFYYLEQLILKHKAHENTLGIKPEHGGLDFFYA 209
            ||:|||:||||.||||||:.:|||||:..:|||||||||.||||:.|:|||.:|..|.||||:||
Frog   136 VQSQMCDDCHRVEAKDFWKAVVQVRQKVLHKKTFYYLEQTILKHRLHQNTLRVKEIHDGLDFYYA 200

  Fly   210 NDNHARRMVDFLLTMVPGKVTTSKRLISHDIHSNNYNYKYNWSVEIAPVSKDSAVCLSKKLRHQL 274
            :..||::||:||...||.:...|:||||||||:|.||||..:||||.||.||:.||||.||...|
Frog   201 SKQHAQKMVEFLQCTVPCRFKASQRLISHDIHTNAYNYKSTFSVEIVPVCKDNLVCLSPKLAQSL 265

  Fly   275 GNLSPLVLVNRVSSSIHLIDPLTAQIAELTSQVYFRAPFEAVCNPKQLVEYVVMDIDVIMEKDRK 339
            ||::.:.:..||:|:||||||.|.||||:....|:|:||.::.:||||.|::|||.|::  :|||
Frog   266 GNMNQICICVRVTSTIHLIDPSTLQIAEVDGNTYWRSPFNSLFHPKQLEEFIVMDTDIV--RDRK 328

  Fly   340 TYPGQGQVSFKHALCDIWVVRASELGINDNPIHTRSHLGHLLKVGDSVMGYNTGEANINDLEFDK 404
            ...|.|..|.||.|.::||.:.||:..... .|.|:||||||..||.|:|::....|:||...:|
Frog   329 QAAGAGMRSNKHILAEVWVQKTSEMNTTQQ-YHCRTHLGHLLNPGDLVLGFDLVNCNLNDEFINK 392

  Fly   405 LSSDEIPDVILVRKHYDRQTRLSQRVWKIKHLA--AEATDERSKYDYHEFLDDLEENEDIRGQVN 467
            ::...||||:|::|.|||..|..:|.||:|.:.  .|..|...:..|.:||:||||:|.||..||
Frog   393 MNPHHIPDVVLIKKSYDRTKRQRRRNWKLKEIERDREGMDTDDERQYQDFLEDLEEDEVIRKNVN 457

  Fly   468 IYRDTNKTIPIEVQAAGGDVPQITLEEMLEDMTLECADDEMGEEGGADDTE 518
            ||::.|  :|:|........|:|:|.|||||  |..:.|..|.||....||
Frog   458 IYKNAN--LPVESDTDEEGAPRISLAEMLED--LHISQDATGGEGAEMLTE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmd3	NP_477332.1	NMD3	21..390	CDD:224416	219/369 (59%)
Nmd3	NP_477332.1	NMD3	27..255	CDD:282790	150/228 (66%)
nmd3	NP_989367.2	NMD3	13..388	CDD:224416	221/377 (59%)
nmd3	NP_989367.2	NMD3	17..246	CDD:282790	150/228 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6127
Inparanoid	1	1.050	553	1.000	Inparanoid score	I1107
OMA	1	1.010	-	-		QHG53941
OrthoDB	1	1.010	-	-		D206786at33208
OrthoFinder	1	1.000	-	-		FOG0004479
OrthoInspector	1	1.000	-	-		otm49201
Panther	1	1.100	-	-	LDO	PTHR12746
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R817
SonicParanoid	1	1.000	-	-		X3175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110