DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmd3 and Nmd3

DIOPT Version :9

Sequence 1:	NP_477332.1	Gene:	Nmd3 / 31195	FlyBaseID:	FBgn0023542	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001101152.1	Gene:	Nmd3 / 310512	RGDID:	1308468	Length:	503	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	261/496 - (52%)
Similarity:	353/496 - (71%)	Gaps:	16/496 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ILCCECGVAIQPNPANMCVTCLRNHVDITENIPKQAVLHFCRNCERYLQPPNEWIQAALESRELL 89
            ||||||||.|.|||||:||.|||:.|||::.:|||..:.||:.|:||.|||..|:|.||||||||
  Rat    15 ILCCECGVPISPNPANICVACLRSKVDISQGVPKQVSISFCKQCQRYFQPPASWVQCALESRELL 79

  Fly    90 AICLKKLKG-LKEVKLVDAGFIWTEQHSKRIKVKLTVHGEIIGGTMLQQVFVVEFTVQNQMCNDC 153
            |:||||:|. |.:|:||||||:|||.||||:|||||:..|::.|.:|||||||::.||:|||.||
  Rat    80 ALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDC 144

  Fly   154 HRTEAKDFWRCLVQVRQRAENKKTFYYLEQLILKHKAHENTLGIKPEHGGLDFFYANDNHARRMV 218
            ||.||||||:.::||||:..:|||||||||||||:..|:|||.||..|.||||:|::..||::||
  Rat   145 HRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMV 209

  Fly   219 DFLLTMVPGKVTTSKRLISHDIHSNNYNYKYNWSVEIAPVSKDSAVCLSKKLRHQLGNLSPLVLV 283
            :||...||.:..:|:||||.|||||.||||..:||||.|:.||:.||||.||...|||::.:.:.
  Rat   210 EFLQGTVPCRYKSSQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICIC 274

  Fly   284 NRVSSSIHLIDPLTAQIAELTSQVYFRAPFEAVCNPKQLVEYVVMDIDVIMEKDRKTYPGQGQVS 348
            .||:|:||||||.|.|:|::....::..||.::|:||||.|::|::..::  :|.|...|.|.:|
  Rat   275 IRVTSAIHLIDPNTLQVADIDGNTFWSHPFNSLCHPKQLEEFIVIECSIV--RDLKRNAGAGVIS 337

  Fly   349 FKHALCDIWVVRASELGINDNPIHTRSHLGHLLKVGDSVMGYNTGEANINDLEFDKLSSDEIPDV 413
            .||.|.::|:.:.||:. .|.....|:||||||..||.|:|::....|:||...:|:.||.:|||
  Rat   338 KKHTLGEVWIQKTSEMD-TDKQYFCRTHLGHLLNPGDLVLGFDLANCNLNDEHVNKMKSDRVPDV 401

  Fly   414 ILVRKHYDRQTRLSQRVWKIKHLA-----AEATDERSKYDYHEFLDDLEENEDIRGQVNIYRDTN 473
            :|::|.|||..|..:|.||:|.||     .:..|||   .|.:||:||||:|.||..||||||:
  Rat   402 VLIKKSYDRTKRQRRRNWKLKELARDREDMDTDDER---QYQDFLEDLEEDETIRKNVNIYRDS- 462

  Fly   474 KTIPIEVQAAGGDVPQITLEEMLEDMTLECADDEMGEEGGA 514
             |:|:|........|:|:|.|||||  |..:.|..||||.:
  Rat   463 -TVPVESDTDDEGAPRISLAEMLED--LRISQDATGEEGAS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmd3	NP_477332.1	NMD3	21..390	CDD:224416	203/365 (56%)
Nmd3	NP_477332.1	NMD3	27..255	CDD:282790	144/228 (63%)
Nmd3	NP_001101152.1	NMD3	17..246	CDD:398579	145/229 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346522
Domainoid	1	1.000	322	1.000	Domainoid score	I1178
eggNOG	1	0.900	-	-		E1_COG1499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6127
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1132
OMA	1	1.010	-	-		QHG53941
OrthoDB	1	1.010	-	-		D206786at33208
OrthoFinder	1	1.000	-	-		FOG0004479
OrthoInspector	1	1.000	-	-		oto98271
orthoMCL	1	0.900	-	-		OOG6_101748
Panther	1	1.100	-	-	LDO	PTHR12746
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3175
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810