DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmd3 and nmd3

DIOPT Version :9

Sequence 1:	NP_477332.1	Gene:	Nmd3 / 31195	FlyBaseID:	FBgn0023542	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_593077.1	Gene:	nmd3 / 2542319	PomBaseID:	SPAC16C9.03	Length:	498	Species:	Schizosaccharomyces pombe

Alignment Length:	518	Identity:	218/518 - (42%)
Similarity:	316/518 - (61%)	Gaps:	46/518 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDHEYVGVS-----PLGAADGKGAGSNAVILCCECGVAIQPNPANMCVTCLRNHVDITENIPKQA 60
            ||...:||:     |:.          :.||||||||...||.|.||:.|::...|||..||:::
pombe     3 MDSGSMGVAFQPSEPIA----------STILCCECGVPTPPNAAAMCMDCIKMTTDITSGIPRES 57

  Fly    61 VLHFCRNCERYLQPPNEWIQAALESRELLAICLKKLKGLKEVKLVDAGFIWTEQHSKRIKVKLTV 125
            .::.||.||||:||||.|:.|.||||||:|||||||:||.:|:||||.|||||.||:||||||||
pombe    58 TVNHCRECERYMQPPNNWMIAPLESRELMAICLKKLRGLNQVRLVDANFIWTEPHSRRIKVKLTV 122

  Fly   126 HGEIIGGTMLQQVFVVEFTVQNQMCNDCHRTEAKDFWRCLVQVRQRAENKKTFYYLEQLILKHKA 190
            ..|....|:|||.|.|||.|.|..|.||.||.....|:.:.||||:..:|:||.||||:||||||
pombe   123 QKEAFTNTILQQSFQVEFYVNNTQCPDCARTYTPHIWKAVCQVRQKVLHKRTFLYLEQIILKHKA 187

  Fly   191 HENTLGIKPEHGGLDFFYANDNHARRMVDFLLTMVPGKVTTSKRLISHDIHSNNYNYKYNWSVEI 255
            |.||:.||....|:||::....||.:||:||..:||.:...|:.|||.|..||..|||:.:|:||
pombe   188 HMNTVNIKETKDGIDFYFGQRAHAIKMVEFLSAVVPIRYKGSEELISEDFKSNTANYKFTYSIEI 252

  Fly   256 APVSKDSAVCLSKKLRHQLGNLSPLVLVNRVSSSIHLIDPLTAQIAELTSQVYFRAPFEAVCNPK 320
            .|:.||..|||.|.:....||::.||:..:|..:|..:||||.|..::...:|:|.||.|:.:..
pombe   253 VPICKDDLVCLPKTVAKAHGNIAQLVVCTKVGPTIRFLDPLTLQTCDMLPSIYWRTPFPALADIP 317

  Fly   321 QLVEYVVMDIDVIMEKDRKTYPGQGQVSFKHALCDIWVVRASELGINDNPIH-TRSHLGHLLKVG 384
            :|.|::|.|:|::           |..:.|:||.|:.::::|     |...| ||:|||.:|..|
pombe   318 ELTEFIVADVDLL-----------GPTNGKYALADVELIKSS-----DGSTHLTRTHLGGILNAG 366

  Fly   385 DSVMGYNTGEANINDLEFDKLSSDEIPDVILVRKHYDRQTRLSQRVWKIKHLAAEATD------- 442
            ::|:.|:....|.|:..:|.|..|.||:|::|:|.|. ||:...|.|::|.:..:..:
pombe   367 NTVLAYHLAVTNFNNEVYDTLREDSIPEVVIVKKTYP-QTKKKNRNWRLKTIGMQKAEDVKKQDI 430

  Fly   443 ERSKYDYHEFLDDLEENEDIRGQVNIYRDTNKTIPI------EVQAAGGDVPQITLEEMLEDM 499
            ||.:.||..||.:|||:.::|..||:|:...|.|.:      |......|:|||:::|:|:|:
pombe   431 ERQERDYELFLQNLEEDPELRQGVNLYKAPVKAIAVADTDMDEEDEVDEDIPQISVDELLDDV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmd3	NP_477332.1	NMD3	21..390	CDD:224416	173/369 (47%)
Nmd3	NP_477332.1	NMD3	27..255	CDD:282790	125/227 (55%)
nmd3	NP_593077.1	NMD3	18..385	CDD:224416	176/392 (45%)
nmd3	NP_593077.1	NMD3	24..252	CDD:282790	125/227 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	271	1.000	Domainoid score	I330
eggNOG	1	0.900	-	-		E1_COG1499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6127
Inparanoid	1	1.050	422	1.000	Inparanoid score	I345
OMA	1	1.010	-	-		QHG53941
OrthoFinder	1	1.000	-	-		FOG0004479
OrthoInspector	1	1.000	-	-		oto101864
orthoMCL	1	0.900	-	-		OOG6_101748
Panther	1	1.100	-	-	LDO	PTHR12746
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R817
SonicParanoid	1	1.000	-	-		X3175
TreeFam	1	0.960	-	-
	14	13.860