DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pn and prune

DIOPT Version :9

Sequence 1:	NP_476684.1	Gene:	pn / 31194	FlyBaseID:	FBgn0003116	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001153766.1	Gene:	prune / 563343	ZFINID:	ZDB-GENE-100609-1	Length:	447	Species:	Danio rerio

Alignment Length:	363	Identity:	124/363 - (34%)
Similarity:	199/363 - (54%)	Gaps:	26/363 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LHLVMGNESCDLDSAVSAVTLA-FVYAQRHREHDYVPILNIPRRDYPLKTEVGHLFVKCGIAEPV 100
            ||:|||||:||:||.|||:|.| |:......:...||:|||||.::||:::...|..:.|:::..
Zfish    22 LHVVMGNEACDMDSMVSALTFAYFLSKSLDCKRIPVPVLNIPRAEFPLRSDSIFLLRESGLSQDY 86

  Fly   101 LLFRDDIPREVV---QDVNVILVDHHVSPLAPN-----VTEILDHRPLEDSSPSFKQLPTLCQLD 157
            |||||::....:   :.:.:.||||:|.|.|.:     |.|::||..|:..|.|       |.:.
Zfish    87 LLFRDEVDLHGLHKNKQLTLTLVDHNVLPSADSELEDAVVEVIDHHLLQRPSSS-------CPIT 144

  Fly   158 IDASVGSCATLVAQRYLAEDQPR--STSVAQLLHATIVLDTINFAPAAKRYGPKDEAMVQKLESE 220
            :: .||||.|||.:| :|:..|.  ...|||||:.||:||.:|.||.|.:..|||......||..
Zfish   145 VE-PVGSCTTLVTER-IAQKSPAVLDQQVAQLLYGTIILDCVNMAPEAGKVTPKDSQYAIFLEQR 207

  Fly   221 LNRKDAQRSSLFDELVAARADISKLTLTEVLRKDMKVLQTDRQVVPLAGMPILVRDFVEKSGAEK 285
            . .|...|.:||..|..|:.|:|.|:..::|.||||........:.::.:.:.:.||:::||.::
Zfish   208 F-PKLPPRGALFQSLQNAKFDVSGLSTEQMLLKDMKAASGGDLRLAVSVIYMTLEDFLQRSGLQQ 271

  Fly   286 AVREFGVESNLLVILGMYVSPADGQVQ-RDLALISLSGQGQFVQRVQQALMESNDPKLELRPHEV 349
            .:.||....|..::|.|.:|..|.:.. |.||:.|.|  ..:.:.:.:||.::.:|.|||:|  :
Zfish   272 DLCEFCHSHNYNLLLAMTISFKDSKEPFRQLAVYSSS--TVYREEMSKALEKAKNPSLELKP--L 332

  Fly   350 DTRFMGGCFLRQHNVQATRKHILPIVKRALLEWEADHA 387
            .:.:.......|.|..|:||.::||:...|.|.|...|
Zfish   333 SSPYPDVKAFIQGNTLASRKKVMPIITDFLKEKERREA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pn	NP_476684.1	PPX1	39..379	CDD:224148	118/351 (34%)
pn	NP_476684.1	DHHA2	235..377	CDD:280923	40/142 (28%)
prune	NP_001153766.1	PPX1	25..365	CDD:224148	119/353 (34%)
		DHH	<108..176	CDD:279679	29/76 (38%)
		DHHA2	221..360	CDD:280923	40/142 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586892
Domainoid	1	1.000	90	1.000	Domainoid score	I7791
eggNOG	1	0.900	-	-		E1_COG1227
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41429
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4122
OMA	1	1.010	-	-		QHG59046
OrthoDB	1	1.010	-	-		D1545660at2759
OrthoFinder	1	1.000	-	-		FOG0005774
OrthoInspector	1	1.000	-	-		oto40568
orthoMCL	1	0.900	-	-		OOG6_103741
Panther	1	1.100	-	-	LDO	PTHR12112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R978
SonicParanoid	1	1.000	-	-		X6260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800