DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pn and Prune1

DIOPT Version :9

Sequence 1:	NP_476684.1	Gene:	pn / 31194	FlyBaseID:	FBgn0003116	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001007698.1	Gene:	Prune1 / 310664	RGDID:	1359521	Length:	454	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	126/372 - (33%)
Similarity:	190/372 - (51%)	Gaps:	55/372 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RKLHLVMGNESCDLDSAVSAVTLAFVYAQRHREHD-YVPILNIPRRDYPLKTEVGHLFVKCGIAE 98
            |.||:|:|||:|||||.|||:.|||...:.....| ::|:|||.|.:.||:.:......:..|||
  Rat    16 RPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIAE 80

  Fly    99 PVLLFRDDIPREVVQ---DVNVILVDHHVSP-----LAPNVTEILDHRPLEDSSPSFKQLPTLCQ 155
            ..|:|||:|....:.   .:.:||||||:.|     |...|.|:|||||:|.     |..|. |.
  Rat    81 SALIFRDEIDLLALHQAGQLTLILVDHHMLPKSDAALEEAVAEVLDHRPIEQ-----KYCPP-CH 139

  Fly   156 LDIDASVGSCATLVAQRYL---AEDQPRSTSVAQLLHATIVLDTINFAPAAKRYGPKDEAMVQKL 217
            :.::. |||||||||:|.|   .|...|.|  |.|||.||:||.:|......:...||...|:||
  Rat   140 VSVEL-VGSCATLVAERILQGAPETLDRQT--AALLHGTIILDCVNMDAKIGKATLKDNEYVEKL 201

  Fly   218 ESEL----NRKDAQRSSLFDELVAARADISKLTLTEVLRKDMKVLQTDRQVVPLAGMPILVRDFV 278
            |:..    .|||     :||.|..|:.|:|.||..::||||.|.:......|.::.:.:.:..|:
  Rat   202 EALFPDLPKRKD-----IFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGTKVAVSAVYMDLEAFL 261

  Fly   279 EKSGAEKAVREFGVES--NLLVILGMYVSPADGQVQRDLAL--------ISLSGQGQFVQRVQQA 333
            ::||....:..|..:.  :.||.:.::.:..:..| |.||:        :::.|          .
  Rat   262 QRSGLLSDLSAFCQDHSYDALVAMAIFFNTHNEPV-RQLAIFCPHEALRMTICG----------V 315

  Fly   334 LMESNDPKLELRP-HEVDTRFMGGCFLRQHNVQATRKHILPIVKRAL 379
            |.:|..|.|:|.| ..:.....  .:| |.|.|.:||.:||:::.||
  Rat   316 LEQSTSPALKLTPIPSISAHLQ--AYL-QGNTQVSRKKLLPVLQEAL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pn	NP_476684.1	PPX1	39..379	CDD:224148	121/366 (33%)
pn	NP_476684.1	DHHA2	235..377	CDD:280923	37/152 (24%)
Prune1	NP_001007698.1	PRK05427	20..361	CDD:235458	123/368 (33%)
		DHH motif. /evidence=ECO:0000250	106..108		1/1 (100%)
		DHHA2	218..357	CDD:280923	37/152 (24%)
		Essential for homodimerization. /evidence=ECO:0000250	394..421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..421
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345916
Domainoid	1	1.000	97	1.000	Domainoid score	I7116
eggNOG	1	0.900	-	-		E1_COG1227
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41429
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4170
OMA	1	1.010	-	-		QHG59046
OrthoDB	1	1.010	-	-		D1545660at2759
OrthoFinder	1	1.000	-	-		FOG0005774
OrthoInspector	1	1.000	-	-		oto96004
orthoMCL	1	0.900	-	-		OOG6_103741
Panther	1	1.100	-	-	LDO	PTHR12112
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6260
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770