DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pn and SPAC2F3.11

DIOPT Version :9

Sequence 1:	NP_476684.1	Gene:	pn / 31194	FlyBaseID:	FBgn0003116	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_594390.1	Gene:	SPAC2F3.11 / 2541853	PomBaseID:	SPAC2F3.11	Length:	384	Species:	Schizosaccharomyces pombe

Alignment Length:	410	Identity:	108/410 - (26%)
Similarity:	183/410 - (44%)	Gaps:	79/410 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RFLAQARGTLGRHLAEASPVAWAAAPDVSGRKLHLVMGNESCDLDSAVSAVTLAFVYAQRHREHD 69
            |||...|..:...|..||.|  ::||..|     .|.||||.||||..|::..|:...::.....
pombe     5 RFLENGREQIRNLLLNASTV--SSAPSFS-----FVSGNESADLDSCASSIVYAYCLQRKQLGRI 62

  Fly    70 YVPILNIPRRDYPLKTEVGHLFVKCGIAEPVLLFRDDI---PREVVQDVNVILVDHH------VS 125
            .||..||||::..|:.|:.:|.....|:...::|.|||   |:.:..: .:.||||:      :.
pombe    63 VVPFFNIPRKELRLRPELSYLLNLASISSDDIVFLDDIVKLPKRIFSN-PIYLVDHNSLDRKDLE 126

  Fly   126 PLAPNVTEILDHRPLEDSSPSFKQLPTLCQLDIDASVGSCATLVAQRYL-----------AEDQP 179
            ....::..|:||.  :|...|....|.:.:     ..|||.|||.:.::           :|...
pombe   127 NFNGSIAGIIDHH--KDEGGSLHADPRIIE-----ECGSCCTLVCRYFMPVIRSLYDSKVSELHQ 184

  Fly   180 RSTSVAQLLHATIVLDTINFAPAAKRYGPKDEAMVQ---KLESELNR---KDAQRSSLFDELVAA 238
            .:|::|.|....|::||.|.         |:|....   |:.::|..   ||..|...||.|...
pombe   185 TATNLAVLALGPILIDTGNL---------KNEKTTDTDVKIVNDLCSFVPKDWVRDEFFDTLKEK 240

  Fly   239 RADISKLTLTEVLRKDMKVLQTDRQVVPLA----GMPILVRDFVEKS--GAEKAVREFG-VESNL 296
            :......:..::||:|:|....|..||..|    |:     |:::|.  |.|..::.|. |:::.
pombe   241 KKSCKGFSFDDLLRRDLKQYFPDGIVVNYASVGKGL-----DWIKKKRLGWEDELKSFAEVQNSD 300

  Fly   297 LVILGMYVSPADGQVQRDLALISLSGQG-----QFVQRVQQALMESNDPKLELRPHEVDTRFMGG 356
            |||:|:.:|..| :..|.|.|...:.:|     .|::..:|.|      .||:    ::.:..|.
pombe   301 LVIVGLSLSKND-EFGRQLILYKRTERGAGLADSFLKLSKQNL------GLEI----IEEKDNGD 354

  Fly   357 CFL-RQHNVQATRKHILPIV 375
            ..: .|.|..|:||.::|::
pombe   355 LSMWNQRNSAASRKKVVPLL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pn	NP_476684.1	PPX1	39..379	CDD:224148	97/376 (26%)
pn	NP_476684.1	DHHA2	235..377	CDD:280923	38/154 (25%)
SPAC2F3.11	NP_594390.1	PPX1	28..381	CDD:224148	99/385 (26%)
		DHH	<114..>168	CDD:279679	16/60 (27%)
		DHHA2	237..376	CDD:280923	38/154 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	61	1.000	Domainoid score	I3015
eggNOG	1	0.900	-	-		E1_COG1227
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41429
Inparanoid	1	1.050	89	1.000	Inparanoid score	I1770
OMA	1	1.010	-	-		QHG59046
OrthoFinder	1	1.000	-	-		FOG0005774
OrthoInspector	1	1.000	-	-		oto100714
orthoMCL	1	0.900	-	-		OOG6_103741
Panther	1	1.100	-	-	LDO	PTHR12112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R978
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860