DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pn and Prune1

DIOPT Version :9

Sequence 1:	NP_476684.1	Gene:	pn / 31194	FlyBaseID:	FBgn0003116	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_775482.1	Gene:	Prune1 / 229589	MGIID:	1925152	Length:	454	Species:	Mus musculus

Alignment Length:	379	Identity:	125/379 - (32%)
Similarity:	191/379 - (50%)	Gaps:	55/379 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AAAPDVSGRKLHLVMGNESCDLDSAVSAVTLAFVYAQRHREHD-YVPILNIPRRDYPLKTEVGHL 90
            ||..|  .|.||:|:|||:|||||.|||:.|||...:.....| ::|:|||.|.:.||:.:....
Mouse    10 AALQD--SRPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFF 72

  Fly    91 FVKCGIAEPVLLFRDDIPREVVQ---DVNVILVDHHVSP-----LAPNVTEILDHRPLEDSSPSF 147
            ..:..|.||.|:|||:|....:.   .:.:||||||:.|     |...|.|:|||||:|.
Mouse    73 LQEVKIPEPALIFRDEIDLLALHQAGQLTLILVDHHILPKSDAALEEAVAEVLDHRPIEQ----- 132

  Fly   148 KQLPTLCQLDIDASVGSCATLVAQRYL---AEDQPRSTSVAQLLHATIVLDTINFAPAAKRYGPK 209
            |..|. |.:.::. ||||||||.:|.|   .|...|.|  |.|||.||:||.:|......:..||
Mouse   133 KYCPP-CHVSVEL-VGSCATLVTERILQGAPETLDRQT--AALLHGTIILDCVNMDTNIGKATPK 193

  Fly   210 DEAMVQKLESEL----NRKDAQRSSLFDELVAARADISKLTLTEVLRKDMKVLQTDRQVVPLAGM 270
            |...|::||:..    .|||     :||.|..|:.|:|.||..::||||.|.:......|.::.:
Mouse   194 DSKYVEELEALFPDLPKRKD-----IFDSLQKAKFDVSGLTTEQMLRKDQKTVYRQGTKVAISAI 253

  Fly   271 PILVRDFVEKSGAEKAVREFGVES--NLLVILGMYVSPADGQVQRDLAL--------ISLSGQGQ 325
            .:.::.|::::.....:..|..:.  :.||.:.::.:..:..| |.||:        :::.|
Mouse   254 YMDLKAFLQRTDLFTDLSSFCHDHSYDALVAMTIFFNTQNEPV-RQLAIFCPHEALRMTICG--- 314

  Fly   326 FVQRVQQALMESNDPKLELRPHEVDTRFMGGCFLRQHNVQATRKHILPIVKRAL 379
                   .|..|..|.|:|.|  :.:.........|.|.|.:||.:||:::.||
Mouse   315 -------ILERSTSPPLKLTP--IPSTSPNLQAYHQGNTQVSRKKLLPVLQEAL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pn	NP_476684.1	PPX1	39..379	CDD:224148	117/365 (32%)
pn	NP_476684.1	DHHA2	235..377	CDD:280923	34/151 (23%)
Prune1	NP_775482.1	PPX1	21..286	CDD:224148	99/278 (36%)
		DHH motif. /evidence=ECO:0000250	106..108		1/1 (100%)
		DHHA2	218..357	CDD:280923	34/151 (23%)
		Essential for homodimerization. /evidence=ECO:0000250	394..421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842470
Domainoid	1	1.000	97	1.000	Domainoid score	I7266
eggNOG	1	0.900	-	-		E1_COG1227
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41429
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4284
Isobase	1	0.950	-	0	Normalized mean entropy	S4890
OMA	1	1.010	-	-		QHG59046
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005774
OrthoInspector	1	1.000	-	-		oto92440
orthoMCL	1	0.900	-	-		OOG6_103741
Panther	1	1.100	-	-	LDO	PTHR12112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R978
SonicParanoid	1	1.000	-	-		X6260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740