DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pn and PRUNE2

DIOPT Version :9

Sequence 1:	NP_476684.1	Gene:	pn / 31194	FlyBaseID:	FBgn0003116	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_006717045.1	Gene:	PRUNE2 / 158471	HGNCID:	25209	Length:	3104	Species:	Homo sapiens

Alignment Length:	404	Identity:	93/404 - (23%)
Similarity:	169/404 - (41%)	Gaps:	84/404 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLAQARGTLGRHLAEASPVAWAAAPDVSGR--KLHLVMGNESCDLDSAVSAVTLAFVYAQRHREH 68
            ||.:|:..|.|                |.|  |:|:|:|.:||||||.:|..|.|:..
Human     4 FLQRAKSKLNR----------------SKRLEKVHVVIGPKSCDLDSLISTFTYAYFL------- 45

  Fly    69 DYV--------PILNIPRRDYPLKTEVGHLFVKCGIAEPVLLFRDDIPREVVQD---VNVILVDH 122
            |.|        |:|||||.::...||...:..:..|:|...:|||:|....:.|   :::.||..
Human    46 DKVSPPGVLCLPVLNIPRTEFNYFTETRFILEELNISESFHIFRDEINLHQLNDEGKLSITLVGS 110

  Fly   123 HV-----SPLAPNVTEILDHRPLEDSSPSFKQLPTLCQLDIDASV---GSCATLVAQRYLAEDQP 179
            .|     ..|...|.::::  |:|.|               ||:|   .|.::||.:..|.|...
Human   111 SVLASEDKTLESAVVKVIN--PVEQS---------------DANVEFRESSSSLVLKEILQEAPE 158

  Fly   180 RST-SVAQLLHATIVLDTINFAPAAKRYGPKDEAMVQKLESELNRKDAQRSSLFDELVAARADIS 243
            ..| .:|..|..:|:...:..  .:::...|.|.::..||.:.... ..|..:.:.|...:....
Human   159 LITEQLAHRLRGSILFKWMTM--ESEKISEKQEEILSILEEKFPNL-PPREDIINVLQETQFSAQ 220

  Fly   244 KLTLTEVLRKDMKVLQTDRQVVPLAGMPILVRDFVEKSGAEKAVR----EFGVESNLLVILGMYV 304
            .|::.:.:.||:|.|......|.::.:.:.:.:.:..|.....::    :||.:  :|::...|:
Human   221 GLSIEQTMLKDLKELSDGEIKVAISTVSMNLENCLFHSNITSDLKAFTDKFGFD--VLILFSSYL 283

  Fly   305 SPADGQVQRDLALISLSGQGQFVQRVQQALMESNDPKLELRPHEVDTRFMGGC----FLRQHNVQ 365
            | .:.|.:|.:|:  .|...:...::...|.|..:|.|||.|      |..||    ..:|.:..
Human   284 S-EEQQPRRQIAV--YSENMELCSQICCELEECQNPCLELEP------FDCGCDEILVYQQEDPS 339

  Fly   366 ATRKHILPIVKRAL 379
            .|...::.:||..:
Human   340 VTCDQVVLVVKEVI 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pn	NP_476684.1	PPX1	39..379	CDD:224148	84/367 (23%)
pn	NP_476684.1	DHHA2	235..377	CDD:280923	30/149 (20%)
PRUNE2	XP_006717045.1	PPX1	24..278	CDD:224148	64/282 (23%)
		DHHA2	221..315	CDD:280923	18/98 (18%)
		BNIP2	2799..2909	CDD:289278
		CRAL_TRIO_2	2921..3042	CDD:290435
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1227
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1545660at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.780