DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and DIT2

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_010690.1	Gene:	DIT2 / 852011	SGDID:	S000002810	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	128/542 - (23%)
Similarity:	217/542 - (40%)	Gaps:	111/542 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LVVLLVALLVTRLVASLFRLALKELRHPLQGVVPS----VSRVPLLGAAWQMRSFQPD--NLHDK 60
            |:.||..:|...|....|.:.:..|..|..  :|:    |..:|::        |..|  .|:|.
Yeast     3 LLKLLCLILFLTLSYVAFAIIVPPLNFPKN--IPTIPFYVVFLPVI--------FPIDQTELYDL 57

  Fly    61 F-AEYVKRFG--RSFMGTVLGHVVMVTAEPRHI----DALLQGQHQLKKGTMYFALRGWLGDGLL 118
            : .|.::::|  :.|.|:....:|..:.....|    |...:..:|  |...|.||..:.||.::
Yeast    58 YIRESMEKYGAVKFFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQ--KKIPYSALAAYTGDNVI 120

  Fly   119 LSRGKEWHTMRKIITPTF-HFSILEQFVEVFDRQSSILVERLRT-LSYGNEVVNIYPLVGLAALD 181
            .:.|..|...|..:|... ||.....|     :.:.||...::. |..|...:.:.||....|||
Yeast   121 SAYGAVWRNYRNAVTNGLQHFDDAPIF-----KNAKILCTLIKNRLLEGQTSIPMGPLSQRMALD 180

  Fly   182 IITETAMGVNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLH 246
            .|::.|:|.:..|...:....|  :.|..|....|....|.||.|..|..||. :|....|:..
Yeast   181 NISQVALGFDFGALTHEKNAFH--EHLIRIKKQIFHPFFLTFPFLDVLPIPSR-KKAFKDVVSF- 241

  Fly   247 EFTNGIIEQRRRLLAREANQDKPTKPHALLDT------LLRATVDGQPLTDKQIRDEVNTFIFEG 305
                      |.||.:.. ||:....:....|      |:||. :.:.:..||:.|.:...:..|
Yeast   242 ----------RELLVKRV-QDELVNNYKFEQTTFAASDLIRAH-NNEIIDYKQLTDNIVIILVAG 294

  Fly   306 HDTTTSAVSFCLYLLSRH-EAVQQKLFEELRMHYGQDLFRGVILSD---FATLPYLSCVVKESLR 366
            |:......:..||||::: ...|:||.:|:         .|:  :|   .|.||.|:..:.|.:|
Yeast   295 HENPQLLFNSSLYLLAKYSNEWQEKLRKEV---------NGI--TDPKGLADLPLLNAFLFEVVR 348

  Fly   367 LYPPIPAVA-RCLEK------DLVIDE----GYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERH 420
            :|||:..:. ||..|      ::||.:    ||...||:.....|....|:        |:|||
Yeast   349 MYPPLSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADD--------FKPER- 404

  Fly   421 LGEEAPRL--------SPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHY----------QLL 467
            .|.:...:        :..:...|..|.|.|:|:|.||.||:..:.::::.:          :|.
Yeast   405 WGSDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEKLT 469

  Fly   468 PMGADVEPSIKIVLRSKSGVNV 489
            |.|    |...:.|:.|...|:
Yeast   470 PAG----PLCPLNLKLKFNENI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	119/504 (24%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	111/466 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000