DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and CYP704B1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_177109.3	Gene:	CYP704B1 / 843283	AraportID:	AT1G69500	Length:	524	Species:	Arabidopsis thaliana

Alignment Length:	547	Identity:	146/547 - (26%)
Similarity:	243/547 - (44%)	Gaps:	77/547 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAA-WQMRSFQPDNLHDKFAEY 64
            |.:.|::|.:||..: .|.|...:....|        ...||:||| .|:.:|  |.:||...||
plant     1 MSLCLVIACMVTSWI-FLHRWGQRNKSGP--------KTWPLVGAAIEQLTNF--DRMHDWLVEY 54

  Fly    65 VKRFGRSFMGTVLGHVVMVT----AEPRHIDALLQGQ-HQLKKGTMYFA-LRGWLGDGLLLSRGK 123
            :..     ..||:..:...|    |:|.:::.:|:.. ....||..|.: :...||||:..|.|:
plant    55 LYN-----SRTVVVPMPFTTYTYIADPINVEYVLKTNFSNYPKGETYHSYMEVLLGDGIFNSDGE 114

  Fly   124 EWHTMRKIITPTFHFSI--LEQF-VEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITE 185
            .|...||  |.:|.|:.  |..| ..||...|..|...|...|:..:.|::..|:....||.|.:
plant   115 LWRKQRK--TASFEFASKNLRDFSTVVFKEYSLKLFTILSQASFKEQQVDMQELLMRMTLDSICK 177

  Fly   186 TAMGVNVDAQGADSEVVHAVK--DLTNILAT-RFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHE 247
            ...||.:.....:....|..|  |..||:.| ||:.|.........:...:...|   .:..:::
plant   178 VGFGVEIGTLAPELPENHFAKAFDTANIIVTLRFIDPLWKMKKFLNIGSEALLGK---SIKVVND 239

  Fly   248 FTNGIIEQRRRLLAREANQDKPTK---------PHALLDTLLRATVD-GQPLTDKQIRDEVNTFI 302
            ||..:|.:|:..|. || |..||.         .|.:|...:..:.| ....|:|.:||.|..|:
plant   240 FTYSVIRRRKAELL-EA-QISPTNNNNNNNNKVKHDILSRFIEISDDPDSKETEKSLRDIVLNFV 302

  Fly   303 FEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELR-------------MH---------YGQDL--F 343
            ..|.|||.:.:::.:|::..:|.|.:||:.||:             :|         :.:.:  |
plant   303 IAGRDTTATTLTWAIYMIMMNENVAEKLYSELQELEKESAEATNTSLHQYDTEDFNSFNEKVTEF 367

  Fly   344 RGVILSD-FATLPYLSCVVKESLRLYPPIPAVAR-CLEKDLVIDEGYIPVGTNVVVLLWQLLRDE 406
            .|::..| ...|.||..|:.|:|||||.:|...: .||.|::.:...:..|..|..:.:.:.|.|
plant   368 AGLLNYDSLGKLHYLHAVITETLRLYPAVPQDPKGVLEDDMLPNGTKVKAGGMVTYVPYSMGRME 432

  Fly   407 AIF-TDPLVFQPERHLGEEA-PRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQ--LL 467
            ..: :|..:|:|||.|.:.. ...||:.:..|.||||.|:|:..|.|:||..:..:.|.|:  |:
plant   433 YNWGSDAALFKPERWLKDGVFQNASPFKFTAFQAGPRICLGKDSAYLQMKMAMAILCRFYKFHLV 497

  Fly   468 PMGADVEPSIKIVLRSKSGVNVGLRPR 494
            | ...|:..:..:|....|:.|.:..|
plant   498 P-NHPVKYRMMTILSMAHGLKVTVSRR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	135/503 (27%)
CYP704B1	NP_177109.3	PLN03195	1..524	CDD:215627	146/547 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910