DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ae1 and CYP709B1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_566092.1	Gene:	CYP709B1 / 819310	AraportID:	AT2G46960	Length:	519	Species:	Arabidopsis thaliana

Alignment Length:	550	Identity:	134/550 - (24%)
Similarity:	241/550 - (43%)	Gaps:	91/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVLLVALLVTRLVASL--FRLALKELRHPL--------QGV--------VPSVSRVPLLGAAW 47
            |.:|:.:||:|..|:..|  |:..:..:.||.        ||:        ..::|.:..:....
plant     1 MGLVIFLALIVLILIIGLRIFKAFMILVWHPFVLTRRLKNQGISGPNYRIFYGNLSEIKKMKRES 65

  Fly    48 QMRSFQPDN------LHDKFAEYVKRFGRSFM---GTVLGHVVMVTAEPRHIDALLQGQHQLKKG 103
            .:....|.:      :...:.:::.::|.:|:   ||          |||    :.....:|.|
plant    66 HLSILDPSSNDIFPRILPHYQKWMSQYGETFLYWNGT----------EPR----ICISDPELAK- 115

  Fly   104 TMYFALRGWL--------------GDGLLLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSI 154
            ||.....|:.              ..||:...|.:|...|:|:.|.|....|:....|....:..
plant   116 TMLSNKLGFFVKSKARPEAVKLVGSKGLVFIEGADWVRHRRILNPAFSIDRLKIMTTVMVDCTLK 180

  Fly   155 LVERLRTLSYGNEVVNIYPLV---------GLAALDIITETAMGVNVDAQGADSEVVHAVKDLTN 210
            ::|..|..|...|..  :|.:         .|.| |||..:|.|.:. .:|.  ||..:..:|..
plant   181 MLEEWRKESTKEETE--HPKIKKEMNEEFQRLTA-DIIATSAFGSSY-VEGI--EVFRSQMELKR 239

  Fly   211 ILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQRRRLLAREANQDKPTKPHAL 275
            ...|...:  :..|....|..||..|..:..    .:..|.|    :|:::... |.|......|
plant   240 CYTTSLNQ--VSIPGTQYLPTPSNIRVWKLE----RKMDNSI----KRIISSRL-QSKSDYGDDL 293

  Fly   276 LDTLLRA-TVDG--QPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMH 337
            |..||:| ..:|  :.::.::|..|..||.|.||:||::.:::...|||.|:..|:||.||:...
plant   294 LGILLKAYNTEGKERKMSIEEIIHECRTFFFGGHETTSNLLAWTTMLLSLHQDWQEKLREEIFKE 358

  Fly   338 YGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQL 402
            .|::  :......|:.|..::.|:.||||||.|:.|:||....::.:.:..||.||.||:.|.::
plant   359 CGKE--KTPDSETFSKLKLMNMVIMESLRLYGPVSALAREASVNIKLGDLEIPKGTTVVIPLLKM 421

  Fly   403 LRDEAIF-TDPLVFQPERHL-GEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQ 465
            ..|:.:: :|...|.|.|.. |.......|.:.:.||.|||.||||.|.::|.||::|.:::.::
plant   422 HSDKTLWGSDADKFNPMRFANGVSRAANHPNALLAFSVGPRACIGQNFVMIEAKTVLTMILQRFR 486

  Fly   466 LLPMGADVE--PSIKIVLRSKSGVNVGLRP 493
            .:.:..:.:  |...:.::.:.|:.|.|:|
plant   487 FISLCDEYKHTPVDNVTIQPQYGLPVMLQP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	118/489 (24%)
CYP709B1	NP_566092.1	p450	32..517	CDD:299894	123/518 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.060