DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	518	Identity:	151/518 - (29%)
Similarity:	256/518 - (49%)	Gaps:	51/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAW---QMRSFQPDNLHDKFA 62
            :.:|..:||::.:.:    :|.|:.     |.::..:|..|...|.|   ..:..|.||: :...
Mouse    16 LALVFCLALVLMQAM----KLYLRR-----QRLLRDLSPFPGPPAHWLLGHQKFLQEDNM-ETLD 70

  Fly    63 EYVKRFGRSF---MGTVLGHVVMVTAEPRHI-----DALLQGQHQLKKGTMYFALRGWLGDGLLL 119
            |.||:...:|   :|.......:...:...|     |..:|..|||        |...:|.|||.
Mouse    71 EIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKMQYLHQL--------LTPCIGRGLLN 127

  Fly   120 SRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNE-VVNIYPLVGLAALDII 183
            ..|..|...|.::||.||..||:..|:.......:::::...:....| .:.::..:.|..||||
Mouse   128 LDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDII 192

  Fly   184 TETAMG--VNVDAQGADSEVVHAVKDLTNILATR---FMRPHLLFPHLFRLCWPSGFRKQQAGVI 243
            .:.|.|  .|....|.....|.|..:|..|:::|   |...|.:   :|:|. |.|...|:.|.:
Mouse   193 MKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDI---IFKLS-PKGHCFQELGKV 253

  Fly   244 CLHEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATV-DGQPLTDKQIRDEVNTFIFEGHD 307
             :|::|..||:.|:::|..:..||........||.:|.|.. |.:..:|..:|.|||||::.|||
Mouse   254 -IHQYTEKIIQDRKKILKNQVKQDDTQTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHD 317

  Fly   308 TTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIP 372
            .:.:::|:.||.|:.:...|.:...|:|...|..  ..:.......:.|.:..:||:|||.||:|
Mouse   318 ASAASISWLLYCLALNPEHQDRCRTEIRSILGDG--SSITWEQLDEMSYTTMCIKETLRLIPPVP 380

  Fly   373 AVARCLEKDLVIDEGY-IPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPF 436
            :::|.|.|.|.:.:|: :|.|..||:.:|.|..:.|::.||.||.|.|...|.:.:..|.:::||
Mouse   381 SISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPF 445

  Fly   437 SAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADV-EP---SIKIVLRSKSGVNVGLRPRL 495
            |:||||||||:||:||:|..:..::.|:|:.|   |: .|   |...|||.|.|:.:.|:..|
Mouse   446 SSGPRNCIGQQFAMLELKVAIALILLHFQVAP---DLTRPPAFSSHTVLRPKHGIYLHLKKLL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	142/473 (30%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	142/470 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840