DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	168/518 - (32%)
Similarity:	265/518 - (51%)	Gaps:	74/518 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQGVVPSVSRVPLLGA---------AW---------QMRSFQPDNLHDKF-------------AE 63
            |..||.|...:.||||         ||         ::|.|......:.|             .:
  Rat    11 LGSVVTSTWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQSPKRNWFLGHLGVIQSNEEGMQ 75

  Fly    64 YVKRFGRSFMGT---VLGHV--VMVTAEPRHIDALLQGQHQL--KKGTMYFALRGWLGDGLLLSR 121
            .|...|::|...   .||.|  |:...:|..:..|||....:  |..|....|:.||||||.||.
  Rat    76 LVTEMGQTFRDVHLIWLGPVSPVLRLVDPAFVAPLLQAPALVAPKDPTFLHFLKPWLGDGLFLSS 140

  Fly   122 GKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSY-GNEVVNIYPLVGLAALDIITE 185
            |.:|...|:::||.|||.||:.:|:.|::..:|:..:.:.|.. |:..:.::..:.|..||.:.:
  Rat   141 GDKWSRHRRLLTPAFHFDILKPYVKTFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQK 205

  Fly   186 TAMGVNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHL----FRLCWPSGFRKQQAGVIC-- 244
            ...|.:.:.|.:.||.:.|..:|:::  || .|.:.||.:|    :|......|||     .|
  Rat   206 CLFGFDSNCQESPSEYISATLELSSL--TR-KRSYKLFLYLDFLYYRTADGQRFRK-----ACDL 262

  Fly   245 LHEFTNGIIEQRRRLLAR-------EANQDKPTKPHALLDTLLRATVD-GQPLTDKQIRDEVNTF 301
            :|.||:.:|.:|||||:.       |:.....:|....:|.||.|..: |:.|:|:.||.|.:||
  Rat   263 VHSFTDAVIRERRRLLSSQGVDEFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTF 327

  Fly   302 IFEGHDTTTSAVSFCLYLLSRH----EAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVK 362
            :|.|||||.||:|:.||.|:.|    |..:|:::|.||....::    :...|.|.||:|:..:|
  Rat   328 MFGGHDTTASALSWILYNLASHPEYQERCRQEVWELLRDREPEE----IEWDDLAQLPFLTMCIK 388

  Fly   363 ESLRLYPPIPAVARCLEKDLVIDEG-YIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAP 426
            |||||:||...:.|...:|:|:.:| .||.|...|:.::.:..:.:::.||.|:.|.|...|...
  Rat   389 ESLRLHPPAVDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENRQ 453

  Fly   427 RLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIK--IVLRSKSGV 487
            :.||.|:|||||||||||||.||:.|:|..|...:..::.||  .|.||..|  ::||::.|:
  Rat   454 KRSPLSFIPFSAGPRNCIGQTFAMNEVKVAVGLTLLRFRFLP--DDKEPRRKPELILRAEGGL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	164/510 (32%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	155/455 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840