Protein Alignment Cyp4ae1 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 140/441 - (31%)
• Similarity: 250/441 - (56%)
• Gaps: 32/441 - (7%)

  Fly    72 FMGTVLGHVVMVTAEPRHIDALLQGQHQL-KKGTMYFA-LRGWLGDGLLLSRGKEWHTMRKIITP 134
            ::|.::..:|:  ..|..|.::......: .|..::.. |:.|||:|:|||.|.:|...|:::||
Human    91 WLGPIIPFIVL--CHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTP 153

  Fly   135 TFHFSILEQFVEVFDRQSSILVERLRTL-SYGNEVVNIYPLVGLAALDIITETAMGVNVDAQGAD 198
            .|||:||:.::.:|::.::|::::.:.| |.|:..::::..:.|..||.:.:.....:...|...
Human   154 AFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP 218

  Fly   199 SEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPS--GFRKQQAGVIC--LHEFTNGIIEQRRRL 259
            ||.:..:.:|:.::..|  ..|:| .|:..|.:.|  |.|..:|   |  :|:||:.:|.:|||.
Human   219 SEYIATILELSALVEKR--SQHIL-QHMDFLYYLSHDGRRFHRA---CRLVHDFTDAVIRERRRT 277

  Fly   260 LAREANQD--KPTKPHALLD----TLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLY 318
            |..:...|  |.......||    .||....||:.|:|:.||.|.:||:|.|||||.|.:|:.||
Human   278 LPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLY 342

  Fly   319 LLSRHEAVQQKLFEELRMHYGQDLFRG-----VILSDFATLPYLSCVVKESLRLYPPIPAVARCL 378
            .|:||...|::..:|:     |:|.:.     :...|.|.||:|:..|||||||:||.|.::||.
Human   343 NLARHPEYQERCRQEV-----QELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCC 402

  Fly   379 EKDLVIDEG-YIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRN 442
            .:|:|:.:| .||.|...::.:..:..:..::.||.|:.|.|...|.:...||.::|||||||||
Human   403 TQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRN 467

  Fly   443 CIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKIVLRSKSGVNVGLRP 493
            ||||.||:.|||.::..::.|::.||...:....:::::|::.|:.:.:.|
Human   468 CIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	138/431 (32%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	139/436 (32%)