DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	509	Identity:	132/509 - (25%)
Similarity:	221/509 - (43%)	Gaps:	95/509 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VPSVSRVPLLG-------AAWQMRSFQPDNLHDKFAEYVKRFGRSFMGTVLG-HVVMVTAEPRHI 90
            :|..:.:|.||       ..|   :|..: .::|:.|        ..|...| ..::|..:|..|
Human    38 IPGPTPLPFLGTILFYLRGLW---NFDRE-CNEKYGE--------MWGLYEGQQPMLVIMDPDMI 90

  Fly    91 DALLQGQ------HQLKKGTMYFALRGWLGDGLLLSRGKEWHTMRKIITPTFHFSILEQFVEVFD 149
            ..:|..:      :|:..|.|     |:|...|..:..:||..:|.:::|.|.....::.|.:..
Human    91 KTVLVKECYSVFTNQMPLGPM-----GFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIIS 150

  Fly   150 RQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNVDAQGADSEVVHAVKDLTNILAT 214
            :...:||..||..:..::.:|:....|...:|:||.|..|||:|:.....:..  :|::..:|..
Human   151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPF--LKNMKKLLKL 213

  Fly   215 RFMRPHLLFPHLFRLCWPSGFRKQQAGVI---CLHEFTNGIIEQRRRLLAR-------------E 263
            .|:.|.||...||....|. |.....|:.   ..|...|.|...:...|..             :
Human   214 DFLDPFLLLISLFPFLTPV-FEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMID 277

  Fly   264 ANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQ 328
            :...|.||.|             :.|:|.::..:....||..:|||::.:.|.:|.|:.|..|||
Human   278 SQNSKETKSH-------------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQ 329

  Fly   329 KLFEELRMHYGQDLFRGVILSDFA--------TLPYLSCVVKESLRLYPPIPAVARCLEKDLVID 385
            ||.||:          ..:|.:.|        .:.||..||.|:|||:|.:..|.|..:||:.|:
Human   330 KLQEEI----------DAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEIN 384

  Fly   386 EGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPE-RHLGEEAPRLSPYSYIPFSAGPRNCIGQKFA 449
            ..:||.|..|:|.::.|..|...:|:|..|.|| |...:....:..|.||||.||||||||.:||
Human   385 GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFA 449

  Fly   450 LLEMKTMVTKVIRHYQL-------LPMGAD----VEPSIKIVLR--SKSGVNVG 490
            |..:|..|.:.::::..       :|:..|    ::|...|||:  .:.|:..|
Human   450 LTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSG 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	130/502 (26%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	130/497 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910