DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	527	Identity:	167/527 - (31%)
Similarity:	275/527 - (52%)	Gaps:	83/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GVVPSVS----RVPLLGAAWQM-----------RSFQPDNLHDKFAEYVKRFGRSFMGTVLGHVV 81
            |:.|.|:    .:.||||:|.:           |:::  :||. |.:..||      ..::|||.
Mouse    10 GLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYR--HLHG-FPQPPKR------NWLMGHVG 65

  Fly    82 MVTAEPRHIDAL--LQGQH---------------------------------QLKKGTMYFALRG 111
            |||...:.:..|  |.|.:                                 .||....|..|:.
Mouse    66 MVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKP 130

  Fly   112 WLGDGLLLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSIL-VERLRTLSYGNEVVNIYPLV 175
            |||||||:|.|.:|...|:::||.|||:||:.:|::|:..::|: .:..|.:|.|:..::::..|
Mouse   131 WLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGSARLDMFEHV 195

  Fly   176 GLAALDIITETAMGVNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQA 240
            .|..||.:.:.....:.:.|...||.:.|:.:|:.::|.|..:| |:|..|.....|.|.|.::|
Mouse   196 SLMTLDSLQKCVFSFDSNCQEKSSEYIAAILELSALVAKRHQQP-LMFMDLLYNLTPDGMRFRKA 259

  Fly   241 GVIC--LHEFTNGIIEQRRRLLAREANQD--KPTKPHALLD----TLLRATVDGQPLTDKQIRDE 297
               |  :||||:.:|.:|.|.|..:...|  |.......||    .||....||:.|:|:.||.|
Mouse   260 ---CNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAE 321

  Fly   298 VNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRG-----VILSDFATLPYL 357
            .:||:|||||||.|.:|:.||.|:||...|::..:|:     |:|.||     :...|.|.||:|
Mouse   322 ADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEV-----QELLRGREPEEIEWDDLAQLPFL 381

  Fly   358 SCVVKESLRLYPPIPAVARCLEKDLVIDEG-YIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHL 421
            :..:||||||:||:..::||..:|:::.:| .||.|...::.::.:..:.:::.||.|:.|.|..
Mouse   382 TMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFD 446

  Fly   422 GEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKIVLRSKSG 486
            .|.....||.::|||||||||||||.||:.|||..:...:..::|||...:.....:::||::.|
Mouse   447 PENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGG 511

  Fly   487 VNVGLRP 493
            :.:.:.|
Mouse   512 LWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	164/515 (32%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	153/473 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740