Protein Alignment Cyp4ae1 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 116/490 - (23%)
• Similarity: 199/490 - (40%)
• Gaps: 71/490 - (14%)

  Fly     3 VVLLVALLVTRLVASLFRLALKELRHPLQGV----------VPSVSR-VPLLGAA--W--QMRSF 52
            :|..:|.|...||:....||:.:....|:..          :|..|. .||:|..  |  |...|
Human     8 LVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGF 72

  Fly    53 QPDNLHDKFAEYVKRFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGL 117
            |....        :::|..|...:||..::......::..:|.|:|.|.......:.|..||...
Human    73 QSSRR--------EKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNT 129

  Fly   118 LL-SRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALD 181
            :. |.|......||:.:..|....||.::   .:...::.:.||..|...|.:|:|.........
Human   130 VSNSIGDIHRNKRKVFSKIFSHEALESYL---PKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFR 191

  Fly   182 IITETAMGVNVDAQGADSEVVHAVKDLTNILATRFMRP-HLLFPHLFRLCWPSGFRKQQAGVICL 245
            :.....:|.::    .:.::.|..:.....:...|..| .|.|         ||:|:
Human   192 MAIRVLLGFSI----PEEDLGHLFEVYQQFVDNVFSLPVDLPF---------SGYRR-------- 235

  Fly   246 HEFTNGIIEQRRRLL-------AREANQDKPTKPHA-LLDTLLRATVD-GQPLTDKQIRDEVNTF 301
                 ||  |.|::|       .||..|....|.:. .||.|:.::.: |:.:|.::::|.....
Human   236 -----GI--QARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLEL 293

  Fly   302 IFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELR----MHYGQDLFRGVI-LSDFATLPYLSCVV 361
            ||..:.||.||.:..:..|.:|..|.:||.:|||    :|.|.....|.: |...:.|.||.||:
Human   294 IFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVI 358

  Fly   362 KESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPER-HLGEEA 425
            ||.:||:.||....|.:.:...:|...||.|.:|:..:........:|.|..||.|:| ......
Human   359 KEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSE 423

  Fly   426 PRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKV 460
            .:...:.|:||..|.|.|:|:..|.|.:|.:..::
Human   424 DKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVEL 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	97/402 (24%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	104/438 (24%)