DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	511	Identity:	122/511 - (23%)
Similarity:	227/511 - (44%)	Gaps:	56/511 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAEYVK 66
            ||||::.|        ||...:...|..::..:|.....|.:|.   :.|: ...|.:...|..|
Zfish    13 LVVLVITL--------LFIYGVWPHRFFIKLGIPGPRPWPFVGT---LLSY-AKGLCNFDMECAK 65

  Fly    67 RFGRSFMGTVLGHV-VMVTAEPRHIDALLQGQ------HQLKKGTMYFALRGWLGDGLLLSRGKE 124
            ::|:.: |...|.: :::.|:...|..:|..:      ::.|:.|   .|.|...||:::.:.:.
Zfish    66 KYGKVW-GIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTT---GLAGPFSDGIIMVKDER 126

  Fly   125 WHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMG 189
            |..||..::|.|....|::...:....:...::.::... ..:.|.|..:|...:||:||.::..
Zfish   127 WKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKD-PEQPVKIKEVVAPYSLDVITSSSFS 190

  Fly   190 VNVDA--QGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGI 252
            |::|:  ...|..|::..|.:...:....:...||||.|       ....::.||....:.....
Zfish   191 VDIDSINNPEDPFVINVKKFIQFNMFNPLLLLILLFPSL-------AIPLKKMGVTLFSKSAMDF 248

  Fly   253 IEQRRRLLAREANQDKPTKPHALL---------DTLLRATVDGQP---LTDKQIRDEVNTFIFEG 305
            .....:.:..:.|::...:...|.         |.:..:....||   |||.:|..:...||..|
Zfish   249 FYSVLKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGG 313

  Fly   306 HDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPP 370
            ::||::.::|.||.|:.:....:||.||:..::..|  ..:.......:.||...:.||:||.|.
Zfish   314 YETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLD--TPITYDALMRMDYLEMAINESMRLLPT 376

  Fly   371 IPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIP 435
            .|.:.|..:|.:||:...||.||.|.:..:.|..|..|:..|..|:|||...|.......|::||
Zfish   377 APRLERSAKKTVVINGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFIP 441

  Fly   436 FSAGPRNCIGQKFALLEMKTMVTKVIRHYQL---------LPMGADVEPSIKIVLR 482
            |..|||||||.::|::.||..|.|:::::.:         |.|....:|.:.|.|:
Zfish   442 FGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNVTFQPKVPITLK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	114/478 (24%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	110/464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000