DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	151/522 - (28%)
Similarity:	252/522 - (48%)	Gaps:	44/522 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVLLVALLVTRL-----------VASLF--RLALKELRHPLQGVVPSVSRVPLLGAAWQMRSF 52
            |:::.|:..|...|           :.|.|  |:.||: ..|::.:.|......:.|....:...
  Fly     1 MIILWLILALSALLYWLHRANKDYHILSFFTKRIRLKD-GTPVEIIAPIAKGKTIFGNTLDLYGR 64

  Fly    53 QPDNLHDKFAEYVKRFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGL 117
            ....:.:...|..|..|.|::..|.|..:....:....:.:|...:.:.||.:|..|..:|..||
  Fly    65 DHAGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLRTGL 129

  Fly   118 LLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDI 182
            |.|.||:||..||::||||||:||.||.|:|..:|...:  |:........:.::.::....|:.
  Fly   130 LTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFL--LQFEGQDEVTITLHDVIPRFTLNS 192

  Fly   183 ITETAMGVNVDAQGADSEVVHA-VKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLH 246
            |.||||||.:|......:.... ...:......|...|.|....||.:.....|   .:.:..:|
  Fly   193 ICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFAAKDF---ASALDVVH 254

  Fly   247 EFTNGIIEQRRRLLAREANQDKPT---------KPHALLDTLLRATVDGQPLTDK-QIRDEVNTF 301
            .|::.||.:||.||..|.::...|         |..|:||||:.|..||  |.|. .|.:||:|.
  Fly   255 RFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTLIYAEKDG--LIDHIGICEEVDTL 317

  Fly   302 IFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLR 366
            :|||:|||:..:.|.|..:|.:...|:..::|::.|...|| ..:.:.....|.||...:||:.|
  Fly   318 MFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDL-SNLDVGQLNKLKYLEYFMKETTR 381

  Fly   367 LYPPIPAVARCLEKDLVIDEGYI-PVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSP 430
            |:|.:|.:.|...::..:..|.| |.|..:.:.::.:.|:...:..|..|:|||.|.|.......
  Fly   382 LFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDRHT 446

  Fly   431 YSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKIV------LRSKSGVNV 489
            |:|:|||||.|||||:|:|:.||||::..:::.:::|..   ::|. |||      ||::..:.|
  Fly   447 YAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKA---IDPQ-KIVFHTGITLRTQDKIRV 507

  Fly   490 GL 491
            .|
  Fly   508 KL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	139/468 (30%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	139/466 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460504
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000