DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and sad

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	139/569 - (24%)
Similarity:	222/569 - (39%)	Gaps:	146/569 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVALLVTRLVASLFRLALKELRHPLQGV---------------VPSVSRVPLLGAAWQM-RSFQ 53
            ||..|||..|..||||.....  .|||..               :|.|..:|::|....: .:..
  Fly    17 LLDQLLVRILSLSLFRSRCDP--PPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGG 79

  Fly    54 PDNLHDKFAEYVKRFG---RSFMGTVLGHVVMVTAE------------PRH--IDA--LLQGQHQ 99
            ..:||.......|::|   |..:|.....|.:.:|.            |:|  .||  |...||.
  Fly    80 ATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHA 144

  Fly   100 LKKGTMYFALRGWLG-----DGLLLSRGKEW------------------HTMRKIITP------- 134
            .::|..:.....||.     :.|||:....|                  .|......|
  Fly   145 CQRGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESGEI 209

  Fly   135 -TFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNVDAQGAD 198
             ::...:|||  ::: |.|   :|.|..:.:|..|:.. |.: .::||..|
  Fly   210 RSYELPLLEQ--QLY-RWS---IEVLCCIMFGTSVLTC-PKI-QSSLDYFT-------------- 252

  Fly   199 SEVVHAVKDLTNILATRFMRPHLLFP----HLFRL-CWPSGFRKQQAGVICLHEFTNGIIEQRRR 258
             ::||.|.:.::.|.|        ||    .:.|| .|    |..:|.|..:......||:...|
  Fly   253 -QIVHKVFEHSSRLMT--------FPPRLAQILRLPIW----RDFEANVDEVLREGAAIIDHCIR 304

  Fly   259 LLAREANQDKPTKPH--ALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLS 321
            :      |:...:||  ||...|..|.|.|    |...|..|:..|..| |||..:..:.|:.||
  Fly   305 V------QEDQRRPHDEALYHRLQAADVPG----DMIKRIFVDLVIAAG-DTTAFSSQWALFALS 358

  Fly   322 RHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDE 386
            :...:||:|.:| |......|..|:|              ||||||||..|.:.|.|.:|..:..
  Fly   359 KEPRLQQRLAKE-RATNDSRLMHGLI--------------KESLRLYPVAPFIGRYLPQDAQLGG 408

  Fly   387 GYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERH-LGEEAPRLSPYSYIPFSAGPRNCIGQKFAL 450
            .:|...|.|::.|:...||.:.|..|....|||. :||.......:..:||:.|.|:|||::.||
  Fly   409 HFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVAL 473

  Fly   451 LEMKTMVTKVIRHYQL-----LPMGADVEPSIKIVLRSKSGVNVGLRPR 494
            .::.:::.:....:::     :|    |:..:::|......:.:.||||
  Fly   474 KQLHSLLGRCAAQFEMSCLNEMP----VDSVLRMVTVPDRTLRLALRPR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	122/514 (24%)
sad	NP_650123.1	p450	63..497	CDD:299894	118/498 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010