DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	158/506 - (31%)
Similarity:	265/506 - (52%)	Gaps:	51/506 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLLVALLVTRLVASLFRLALKELRH--PLQGVVPSVSRVPLLG---------AAWQMRSFQPDNL 57
            :||:||.:..|.....:..:..|.|  |....:|.:..:.:|.         .|.:|.:   ::|
  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMIN---EHL 69

  Fly    58 HDKFAEYVKRFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRG 122
            ||..|       :.:|||.|   .:|...|:.|.||...|..|:|...|.....||.:||..|..
  Fly    70 HDHRA-------KLWMGTKL---YLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGF 124

  Fly   123 KEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETA 187
            ::|...|||:.|.|::::::|||.||::||.||:..:...:...:.::...|:....||.|.|||
  Fly   125 EKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETA 189

  Fly   188 MGVNVDAQ-GADSEVVHAVKDLTNILATR----FMRPHLLFPHLFRLCWPSGFRKQQAGVICLHE 247
            :||:|.:| .|.||.:.|||.:..|:..|    |.|...:|..      .|.::::|..:..||.
  Fly   190 LGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKR------TSHYKREQELIKTLHG 248

  Fly   248 FTNGIIEQR----------RRLLAREANQDKPTKPHALLDTLLRAT-VDGQPLTDKQIRDEVNTF 301
            ||.|||::|          |...:.:|..|...:....|||||.:. .||:|||.|.||:||:|.
  Fly   249 FTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTI 313

  Fly   302 IFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLR 366
            ||.|.|.|.:.::|.:|.::.|...||:..||:....|:|....:.:.....|.:|...:||:||
  Fly   314 IFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLR 378

  Fly   367 LYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPER-HLGEEAPRLSP 430
            :||..|..||....:..|::.:||.|::|::....:.|.:..|.||:||:|:| .:|.| |::..
  Fly   379 MYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAE-PKIEA 442

  Fly   431 YSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKIVL 481
            .::|||.||.|:|:||::|::.:|.::..::|::...|:|   |..:|:.|
  Fly   443 TTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLG---ERQVKLKL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	150/473 (32%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	151/479 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449054
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900