DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4aa1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	154/511 - (30%)
Similarity:	268/511 - (52%)	Gaps:	42/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVLLVALLVTRLVASL---FRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFA 62
            :|::|:::|.:....|:|   .|..|..||  |.| .||   :|.||....:.        ||
  Fly    18 ILILLVISLSIYTFYATLNTYLRSVLLSLR--LTG-PPS---LPFLGNCMLVT--------DK-- 66

  Fly    63 EYVKR-FGRSFMGTVLGHVVMV---------TAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGL 117
            :.::| .|::|  .:.|.:|.:         ..||..:..:|..:....|...|..:..:|||||
  Fly    67 DLMRRCAGKAF--DLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGL 129

  Fly   118 LLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDI 182
            :.|.|.:|...|::|.|.||.::||:|::.|...|..|.|.|...:.|.| :||...|....|||
  Fly   130 ITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTE-INIAKYVNNCVLDI 193

  Fly   183 ITETAMGVNVDAQGADSEVVH--AVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICL 245
            :.|..:||.:..:|.|..::.  ..:....::..||.:|.||...::.  |......:......|
  Fly   194 LNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYH--WTKMANDELNQKKRL 256

  Fly   246 HEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTT 310
            ::||..:|::||::   :.|.:..::...|||.::..:...:..|::.|.:|..||:..|.|:..
  Fly   257 NDFTRKMIQRRRQI---QNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVG 318

  Fly   311 SAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVA 375
            :||:|.|:||:::...|.:...||...: :|..|...::|...:.|:...:||:|||||.:|.:|
  Fly   319 AAVAFTLFLLTQNPECQDRCVLELATIF-EDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIA 382

  Fly   376 RCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGP 440
            |.|.:::.:.:..:|.|:||.:..:...|...|:.||..|||||...|.:....||:::||||||
  Fly   383 RKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGP 447

  Fly   441 RNCIGQKFALLEMKTMVTKVIRHYQLLPM--GADVEPSIKIVLRSKSGVNVGLRPR 494
            |.|||.:||::|:||:|::::|.|||||:  ...:..:.:|.||:..|:.|.|:.|
  Fly   448 RYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKER 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	139/464 (30%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	135/447 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460466
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000