DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_006240610.1	Gene:	Cyp46a1 / 362782	RGDID:	1306605	Length:	500	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	130/462 - (28%)
Similarity:	215/462 - (46%)	Gaps:	56/462 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LHDKFAEYVKRFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGL---- 117
            |.|.|.::.|::|......|.....::...|..:...|......|...||.|::...|:.|
  Rat    60 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAIQTVFGERLFGQG 124

  Fly   118 LLSR---GKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAA 179
            |:|.   |: |:..|:::...|..|.|...:..|:.::..|:|.|...:.|...|::..::..|.
  Rat   125 LVSECDYGR-WYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCAT 188

  Fly   180 LDIITETAMGVNVD-AQGADSEVVHAVKDL-------TNILATRFMRPHLLFPHLFRLCWPSGFR 236
            :||:.:.|.|:... ..||...:..|||.:       .|.|| :||               .|.|
  Rat   189 IDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLA-KFM---------------PGKR 237

  Fly   237 KQ----QAGVICLHEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDE 297
            ||    :..:..|.:.....:::||..|.|  .:|.|..   :|..:|:|....|  .|:.:.|.
  Rat   238 KQLREIRESIRLLRQVGKDWVQRRREALKR--GEDVPAD---ILTQILKAEEGAQ--DDEVLLDN 295

  Fly   298 VNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVK 362
            ..||...||:|:.:.::|.:..|||...:..:|..|:....|..  |.:...|...|.|||.|:|
  Rat   296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSK--RHLDYEDLGRLQYLSQVLK 358

  Fly   363 ESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPR 427
            ||||||||.....|.||::.:||...:|..|.::...:.:.|.:..|.|||.|.|:| .|..||:
  Rat   359 ESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR-FGPGAPK 422

  Fly   428 LSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIR--HYQLLP---MGADVEPSIKIVLRSKSGV 487
             ..::|.|||.|.|:||||:||.:|:|.::.|:::  .::|:|   .|...:.::|.:    ..|
  Rat   423 -PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPL----DPV 482

  Fly   488 NVGLRPR 494
            ...||||
  Rat   483 LCTLRPR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	125/452 (28%)
Cyp46a1	XP_006240610.1	p450	34..466	CDD:278495	123/433 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920