DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4p3

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	157/532 - (29%)
Similarity:	271/532 - (50%)	Gaps:	62/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVLLVALLVTRLVASLFRL--------------ALKELRHPLQGVVPSVSRVPLLGAAWQMRS 51
            ||::.||...:. |:..::||              ..|..::| :.:.|.|....:...::.:..
  Fly     1 MLILWLVGAFIV-LIQWIYRLNRDYCILGFFAKRIRTKNGQNP-ESIAPLVKGSTIFANSFDLYG 63

  Fly    52 FQPDNLHDKFAEYVKRFGRSF----MGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGW 112
            .....:.:...:..|:.|:|:    |||.:.:|:...:..|    :|...:.:.|||:|..|..:
  Fly    64 KDHSGVFEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAER----VLNDPNLINKGTIYDFLHPF 124

  Fly   113 LGDGLLLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNE--VVNIYPLV 175
            |..|||.|.||:||..||:::|||||:||.||.|:|..:|...:|:.:    ||:  ::::..::
  Fly   125 LRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFK----GNDEAIISLNEVI 185

  Fly   176 GLAALDIITETAMGVNVDAQGADSEVVHA-VKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQ 239
            ....|:.|.||||||.:|......:.... .:.:......|...|.|....||::.    ..|..
  Fly   186 PRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMF----AEKDY 246

  Fly   240 AGVI-CLHEFTNGIIEQRRRLLAREANQDKPT-----------KPHALLDTLLRATVDGQPLTDK 292
            |..: .:|.|::.||.:||..|..|.:....|           |..|:||||:.|..||  |.|.
  Fly   247 ASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKDG--LIDH 309

  Fly   293 -QIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVI-LSDFATLP 355
             .|.:||:|.:|||:|||:..:.|.|..:|.:...|:|.::|::.:...:|  .:: :.....|.
  Fly   310 IGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDEL--NILNIGQLNKLK 372

  Fly   356 YLSCVVKESLRLYPPIPAVARCLEKDLVIDEGYI-PVGTNVVVLLWQLLRDEAIFTDPLVFQPER 419
            .|...:||::||:|.:||:.|...::..:..|.| |.|:.:.|.::.:.|:...:..|..|:|||
  Fly   373 NLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPER 437

  Fly   420 HLGEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEP-----SIKI 479
            .|.|.:.....|:|||||||.|||||||||:.||||::..:::.:|:||   :::|     ...:
  Fly   438 FLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILP---EIDPKTIVFQTGL 499

  Fly   480 VLRSKSGVNVGL 491
            .||:|:.::|.|
  Fly   500 TLRTKNQIHVKL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	146/477 (31%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	143/469 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460503
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000