DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	171/516 - (33%)
Similarity:	279/516 - (54%)	Gaps:	39/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LVVLLVALLVTRLVASLFRLAL-KELR----HPLQG---VVPSVSRVPLLGAAWQMRSFQPDNLH 58
            |::..:.||:.:|..:.|.|:| |.:|    .||:.   |||..:|   .|....:.:..|.|:.
  Fly    10 LLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTR---FGNNLDLLNLTPANIF 71

  Fly    59 DKFAE-YVKRFGRSFMGTVL--GHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLS 120
            ....| ..|..|::::...|  ....:|.||  ..:.:.|......|...|..:|.:||||||:|
  Fly    72 SYIRESTAKANGQNYIWNFLFAPEYNIVRAE--DAEEIFQSTKITTKNMSYELIRPFLGDGLLIS 134

  Fly   121 RGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERL-RTLSYGNEVVNIYPLVGLAALDIIT 184
            ..::|||.||.:||.|||:||:.|:.:|..:|...::.| :.:.:..|:..|.|..   .|:.|.
  Fly   135 IDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFELELNQIIPQF---TLNNIC 196

  Fly   185 ETAMGVNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFT 249
            |||:||.:|.....:|...|:.|...:...|...|.:.|...|.|.  ..::|....:..:|.|:
  Fly   197 ETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLF--GDYKKYSRILRTIHGFS 259

  Fly   250 NGIIEQRRRLLAR----EANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTT 310
            :|||:::|:...:    :.::....:.:|:|||||.|..:|: :..:.|.||||||:|.|:|||:
  Fly   260 SGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEGK-IDHQGICDEVNTFMFGGYDTTS 323

  Fly   311 SAVSFCLYLLSRHEAVQQKLFEELRMHYGQDL---FRGVILSDFATLPYLSCVVKESLRLYPPIP 372
            :::.|.|.||:.|..||::.:|||     |||   ...|.:..|..|.:|.||:||||||:|..|
  Fly   324 TSLIFTLLLLALHADVQERCYEEL-----QDLPEDIDEVSMFQFNELIHLECVIKESLRLFPSAP 383

  Fly   373 AVAR-CLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPF 436
            .:.| |:|:. |::...:|....:.:.::.::||...|..|..|.|||.|.|.:....|::::||
  Fly   384 IIGRTCIEES-VMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHPFAFVPF 447

  Fly   437 SAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMG--ADVEPSIKIVLRSKSGVNVGLRPRL 495
            ||||||||||||.:||:|.::..|||:::|||..  .|:.....||||::..:.|....|:
  Fly   448 SAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNIKVKFEARV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	156/464 (34%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	157/469 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460502
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000