DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	172/443 - (38%)
Similarity:	252/443 - (56%)	Gaps:	41/443 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 FGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMRKII 132
            ||:..|       ||.| :|..|..||.....|.|...|..|..|||.|||.:.|:.||..||::
  Fly    71 FGKDLM-------VMFT-DPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLL 127

  Fly   133 TPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNVDAQ-G 196
            ||.|||.||.:|.|..:....|||.||||.:.| |..:|||.:.|.|||.|.|||||:...|| .
  Fly   128 TPGFHFRILSEFKEPMEENCRILVRRLRTKANG-ESFDIYPYITLFALDAICETAMGIKKHAQLQ 191

  Fly   197 ADSEVVHAVKDLTNILATR----FMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQRR 257
            :|||.|.||:.:..::..:    :.|.::.|.|      ....::::|.:..||:.||.:|..||
  Fly   192 SDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKH------TKPGKEREAALKVLHDETNRVIRLRR 250

  Fly   258 RLLAREANQDKPTKPH---------ALLDTLLRATVD-GQPLTDKQIRDEVNTFIFEGHDTTTSA 312
            ..|.:|.|:.||....         |.||.||...:: |..|:|..||:||:||:|||||||:||
  Fly   251 EQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSA 315

  Fly   313 VSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARC 377
            ::|.|.|||::..|||:.|||.....|::.         .::|||..|:||:||:||.:|..:|.
  Fly   316 IAFALSLLSKNPDVQQRAFEEASELEGREK---------ESMPYLEAVIKETLRIYPSVPFFSRK 371

  Fly   378 LEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRN 442
            :.:||.:.:..:|.|.::..|::.|.||...|.||..|.|:|.|..| .::.|:::..|||||||
  Fly   372 VLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNE-KQMHPFAFAAFSAGPRN 435

  Fly   443 CIGQKFALLEMKTMVTKVIRHYQLLP-MGADVEPSIKIVLRSKSGVNVGLRPR 494
            |||||||:||:||.:..::|.|:.|| .....:|..::|.:|.:|:.:.:.||
  Fly   436 CIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILPR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	169/433 (39%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	166/422 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460454
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.910