Protein Alignment Cyp4ae1 and Cyp26c1

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_217935.3
• Gene: Cyp26c1 / 308190
• RGDID: 1308843
• Length: 518
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 126/520 - (24%)
• Similarity: 206/520 - (39%)
• Gaps: 76/520 - (14%)

  Fly     1 MLVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLH-----DK 60
            ||.....|||...|:..|.: .|..||..|.....|...:|.....|   .|..:.||     .:
  Rat    11 MLGAAGTALLCAGLLLGLAQ-QLWTLRWTLSRDWASTLPLPKGSMGW---PFFGETLHWLVQGSR 71

  Fly    61 F-AEYVKRFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKE 124
            | :...:|:|..|...:||..|:..:...::..:|.|:|:|.:.....:....||...||....|
  Rat    72 FHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGE 136

  Fly   125 WHTM-RKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAM 188
            .|.. ||::...|....|||||   .|....|...:|:.......|.:|.........:.....:
  Rat   137 RHRQRRKVLARVFSRPALEQFV---PRLQEALRREVRSWCAAQRPVAVYQAAKALTFRMAARILL 198

  Fly   189 GVNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWP-----SGFRKQQAGVICLHEF 248
            |:.:|......            ||..|.|   |..:||.|  |     ||.||.......|::.
  Rat   199 GLQLDEARCTE------------LAQTFER---LVENLFSL--PLDVPFSGLRKGIRARDQLYQH 246

  Fly   249 TNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVD-GQPLTDKQIRDEVNTFIFEGHDTTTSA 312
            .:.:|.::.|       ::...:|...|..::.:..: |:.|:.:::::.....:|....||.||
  Rat   247 LDEVIAEKLR-------EELTAEPGDALHLIINSARELGRELSVQELKELAVELLFAAFFTTASA 304

  Fly   313 VSFCLYLLSRHEAVQQKLFEELRMH-YGQ-------------------DLFRGVILSDFATLPYL 357
            .:..:.||.:|.|...|:.:||... .|.                   ||...|:    ..|.|:
  Rat   305 STSLILLLLQHPAAIAKIQQELSAQGLGSPCSCAPRASGSRPDCSCEPDLSLAVL----GRLRYV 365

  Fly   358 SCVVKESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIF-TDPLVFQPERHL 421
            .|||||.|||.||:....|...:...:|...||.|.:|:..:.......|:: :.|..|.||| .
  Rat   366 DCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPER-F 429

  Fly   422 GEEAPRL----SPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIR--HYQLLPMGADVEPSIKIV 480
            |.|:...    ..:.||||..|.|:|:||:.|...::.:..:::|  .::|......|..::.||
  Rat   430 GVESEDARGSGGRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPVMQTVPIV 494

  Fly   481  480
              Rat   495  494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	105/439 (24%)
Cyp26c1	XP_217935.3	cytochrome_P450	59..504	CDD:477761	111/468 (24%)