DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	149/492 - (30%)
Similarity:	251/492 - (51%)	Gaps:	25/492 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFRLALKELRHPL--QGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAEYVKRFGRSFMGTVLGH 79
            |||.:..|.::..|  |.::.::.:.|...:.|.......|....:...:|::|..:.:..:.|.
  Rat    26 SLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHDLKDREFQQVLTWVEKFPGACLQWLSGS 90

  Fly    80 VVMVTA-EPRHIDALLQGQHQLKKGTMYFALRGWL----GDGLLLSRGKEWHTMRKIITPTFHFS 139
            ...|.. :|.::..:| |:...|...:|..|..|:    |.||||..||:|....:::||.||:.
  Rat    91 KTRVLLYDPDYVKVVL-GRSDPKASGIYQFLAPWIVSGTGYGLLLLNGKKWFQHWRMLTPAFHYG 154

  Fly   140 ILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAM----GVNVDAQGADSE 200
            ||:.:|::.....||::::...|...:..:.|:..|.|..||.:.:.|.    .|.:|..  ...
  Rat   155 ILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVN--SRS 217

  Fly   201 VVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQRRRLLAREAN 265
            ...||:||.|:  |.|......:.:.......|..|..:......||.|:|:|:.|:..|..|..
  Rat   218 YTKAVEDLNNL--TFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKMRKAQLQNEEE 280

  Fly   266 QDKPTKPHAL--LDTLLRATV-DGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQ 327
            ..|..|...|  ||.||.|.: ||:.|:|:.:|.||:||:|||||||.|.:|:..|.|:.|...|
  Rat   281 LQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQ 345

  Fly   328 QKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEG-YIPV 391
            ::..||::...|..  ..|.......:.|.:..:||:||||||:|:|:|.|...:...:| .||.
  Rat   346 ERCREEVQSILGDG--TSVTWDHLDQISYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRSIPK 408

  Fly   392 GTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTM 456
            |....:|::.|..:.:.:.:|.||.|.| ...::||.| ::|:|||.|.|||||::||:.|:|..
  Rat   409 GITTTILIYGLHHNPSYWPNPKVFDPSR-FSPDSPRHS-HAYLPFSGGARNCIGKQFAMNELKVA 471

  Fly   457 VTKVIRHYQLLPMGADVE-PSIKIVLRSKSGVNVGLR 492
            |...:..::|||....:. |..::||:||:|:::.|:
  Rat   472 VALTLLRFELLPDPTRIPVPMARLVLKSKNGIHLRLK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	141/464 (30%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	139/445 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840