DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ae1 and Cyp12d1-d

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	107/469 - (22%)
Similarity:	203/469 - (43%)	Gaps:	83/469 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MRSFQP--DNLHDKFAEYV----KRFGRSF-MGTVLGHVVMVTA---------------EPRH-- 89
            ||:|.|  :..:....||.    ||:|..: |..:.|....||.               .||.
  Fly    54 MRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDG 118

  Fly    90 IDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMRKIITPTF-HFSILEQFVEVFDRQSS 153
            :|:::..:..::. .:|..::     ||:.|:.:.|..:|..|.|.| ....|..:.|.....::
  Fly   119 LDSIVYFREHVRP-DVYGEVQ-----GLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINN 177

  Fly   154 ILVERLRTL----------SYGNEVVN-IYPLVGLAALDIITETAMGVNVDAQGADSEVVHAVKD 207
            ..:||::.:          .:.:|:.. ::..:||.|.|    ..||           ::...:|
  Fly   178 EFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFD----RQMG-----------LIRKNRD 227

  Fly   208 LTNILATRFMRPHLLF---------PHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQRRRLLARE 263
            .::.| |.|.....:|         |.::::.....:||.:..:......:..::::.:..|.:.
  Fly   228 NSDAL-TLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKMLKENQDALEKR 291

  Fly   264 ANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQ 328
            ....:....:::|:.|:.  :|.:......:     ..:|.|.|.|.:.:|..|..||:|...|.
  Fly   292 RQAGEKINSNSMLERLME--IDPKVAVIMSL-----DILFAGVDATATLLSAVLLCLSKHPDKQA 349

  Fly   329 KLFEELR--MHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEGYIPV 391
            ||.|||.  |.....|.....:.|   :|||..|:||:||.||......|..:.|:::....:|.
  Fly   350 KLREELLSIMPTKDSLLNEENMKD---MPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPK 411

  Fly   392 GTNVVVLLWQLLRDEAIFTDPLVFQPERHLGE----EAPRLSPYSYIPFSAGPRNCIGQKFALLE 452
            ||.|::....|:::...:..|..|.|||.|.:    :..::||::::||..|||.|||::...||
  Fly   412 GTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLE 476

  Fly   453 MKTMVTKVIRHYQL 466
            |:|.|.|:||::.:
  Fly   477 METTVAKLIRNFHV 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	107/469 (23%)
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	103/453 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920