DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	459	Identity:	132/459 - (28%)
Similarity:	236/459 - (51%)	Gaps:	35/459 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QPDNLHDKFAEYVKRFGRSF---MGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLG 114
            |.||: :|..|.::::.|:|   :|..  .......:|.:...||.......:....|: ...||
Human    62 QDDNM-EKLEEIIEKYPRAFPFWIGPF--QAFFCIYDPDYAKTLLSRTDPKSQYLQKFS-PPLLG 122

  Fly   115 DGLLLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTL-SYGNEVVNIYPLVGLA 178
            .||....|.:|...|:::||.|||:||:.::||......:::::...: |..:..|.:|..:...
Human   123 KGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSM 187

  Fly   179 ALDIITETAMG--VNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPH---LFRLCWPSGFRKQ 238
            :||||.:.|..  .|............|:.:|:.|:   |.|.:.|..|   :|:|. |.|:|.|
Human   188 SLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKII---FHRLYSLLYHSDIIFKLS-PQGYRFQ 248

  Fly   239 QAGVICLHEFTNGIIEQRRRLLAREANQDKPTKP--HALLDTLLRATVD-GQPLTDKQIRDEVNT 300
            :...: |:::|:.||::|::.|.....||...|.  ...||.:|.|..: |...:|..:..||:|
Human   249 KLSRV-LNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVST 312

  Fly   301 FIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESL 365
            |:..||||..:::|:.||.|:.:...|::..||:|...|..  ..:.......:.|.:..:||:.
Human   313 FLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDG--SSITWDQLGEMSYTTMCIKETC 375

  Fly   366 RLYPPIPAVARCLEKDLVIDEG-YIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLS 429
            ||.|.:|:::|.|.|.|...:| .:|.|..||:.:|.|..:.|::.:|.||.|.|...|.:.:..
Human   376 RLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRH 440

  Fly   430 PYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKI------VLRSKSGVN 488
            ||:|:|||||.||||||:||::|:|..:..::.|:::.|     :|:..:      :|:.|:|:.
Human   441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP-----DPTRPLTFPNHFILKPKNGMY 500

  Fly   489 VGLR 492
            :.|:
Human   501 LHLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	130/451 (29%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	131/454 (29%)
CYP4X1	NP_828847.1	heme binding region	447..460		10/12 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850