DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	156/514 - (30%)
Similarity:	258/514 - (50%)	Gaps:	49/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVLLVALLVTRLVASLFR--LALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAE 63
            :.:|..:||::.:.|....|  ..|::|| |..|  |:...  |||   ..:..|.||: :|..|
  Rat    16 LALVFCLALVLMQAVKLYLRRQRLLRDLR-PFPG--PTAHW--LLG---HQKFLQEDNM-EKLDE 71

  Fly    64 YVKRFGRSF---MGTVLGHVVMVTAEPRHI-----DALLQGQHQLKKGTMYFALRGWLGDGLLLS 120
            .||.:..:|   :|.......:...:...|     |...|..|||        :..:||.|||..
  Rat    72 IVKEYPCAFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKTQYLHQL--------MTPFLGRGLLNL 128

  Fly   121 RGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERL-RTLSYGNEVVNIYPLVGLAALDIIT 184
            .|..|...|.::||.||..||:..|::.....::::::. :|.:.....:.::..:.|..||||.
  Rat   129 DGPRWFQHRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIM 193

  Fly   185 ETAMG--VNVDAQGADSEVVHAVKDLTNILATR---FMRPHLLFPHLFRLCWPSGFRKQQAGVIC 244
            :.|.|  .|....|.....|.|..:|..|:::|   |...|.:   :|:|. |.|...|:.|.:
  Rat   194 KCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDI---IFKLS-PKGHCFQELGKV- 253

  Fly   245 LHEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATV-DGQPLTDKQIRDEVNTFIFEGHDT 308
            :|:.|..||:.|::.|..:.|||........||.:|.|.. |.:..:|..:|.|||||::.|||.
  Rat   254 IHQCTEKIIQDRKKTLKDQVNQDDTQTSQNFLDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDA 318

  Fly   309 TTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPA 373
            :.:::|:.||.|:.:...|.:...|:|...|..  ..:.......:||.:..:||:|||.||||:
  Rat   319 SAASISWLLYCLALNPEHQDRCRTEIRSILGDG--SSITWEQLDEIPYTTMCIKETLRLIPPIPS 381

  Fly   374 VARCLEKDLVIDEGY-IPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFS 437
            ::|.|.|.|.:.:|: :|.|..||:.:|.|..:.|::.||.||.|.|...|.:.:..|.:::|||
  Rat   382 ISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFS 446

  Fly   438 AGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADV-EP---SIKIVLRSKSGVNVGLR 492
            :||||||||:||:||:|..:...:..::   :.||: .|   |...|||.|.|:.:.|:
  Rat   447 SGPRNCIGQQFAMLELKVAIALTLLRFR---VAADLTRPPAFSSHTVLRPKHGIYLHLK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	144/470 (31%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	138/452 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348515
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850