Protein Alignment Cyp4ae1 and Cyp4x1

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_663708.1
• Gene: Cyp4x1 / 246767
• RGDID: 628719
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 514
• Identity: 156/514 - (30%)
• Similarity: 258/514 - (50%)
• Gaps: 49/514 - (9%)

  Fly     1 MLVVLLVALLVTRLVASLFR--LALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAE 63
            :.:|..:||::.:.|....|  ..|::|| |..|  |:...  |||   ..:..|.||: :|..|
  Rat    16 LALVFCLALVLMQAVKLYLRRQRLLRDLR-PFPG--PTAHW--LLG---HQKFLQEDNM-EKLDE 71

  Fly    64 YVKRFGRSF---MGTVLGHVVMVTAEPRHI-----DALLQGQHQLKKGTMYFALRGWLGDGLLLS 120
            .||.:..:|   :|.......:...:...|     |...|..|||        :..:||.|||..
  Rat    72 IVKEYPCAFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKTQYLHQL--------MTPFLGRGLLNL 128

  Fly   121 RGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERL-RTLSYGNEVVNIYPLVGLAALDIIT 184
            .|..|...|.::||.||..||:..|::.....::::::. :|.:.....:.::..:.|..||||.
  Rat   129 DGPRWFQHRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIM 193

  Fly   185 ETAMG--VNVDAQGADSEVVHAVKDLTNILATR---FMRPHLLFPHLFRLCWPSGFRKQQAGVIC 244
            :.|.|  .|....|.....|.|..:|..|:::|   |...|.:   :|:|. |.|...|:.|.:
  Rat   194 KCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDI---IFKLS-PKGHCFQELGKV- 253

  Fly   245 LHEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATV-DGQPLTDKQIRDEVNTFIFEGHDT 308
            :|:.|..||:.|::.|..:.|||........||.:|.|.. |.:..:|..:|.|||||::.|||.
  Rat   254 IHQCTEKIIQDRKKTLKDQVNQDDTQTSQNFLDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDA 318

  Fly   309 TTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPA 373
            :.:::|:.||.|:.:...|.:...|:|...|..  ..:.......:||.:..:||:|||.||||:
  Rat   319 SAASISWLLYCLALNPEHQDRCRTEIRSILGDG--SSITWEQLDEIPYTTMCIKETLRLIPPIPS 381

  Fly   374 VARCLEKDLVIDEGY-IPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFS 437
            ::|.|.|.|.:.:|: :|.|..||:.:|.|..:.|::.||.||.|.|...|.:.:..|.:::|||
  Rat   382 ISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFS 446

  Fly   438 AGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADV-EP---SIKIVLRSKSGVNVGLR 492
            :||||||||:||:||:|..:...:..::   :.||: .|   |...|||.|.|:.:.|:
  Rat   447 SGPRNCIGQQFAMLELKVAIALTLLRFR---VAADLTRPPAFSSHTVLRPKHGIYLHLK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	132/429 (31%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	138/452 (31%)