Protein Alignment Cyp4ae1 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 140/504 - (27%)
• Similarity: 249/504 - (49%)
• Gaps: 37/504 - (7%)

  Fly     4 VLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAW--QMRSFQPDNLHDKFAEYVK 66
            :||:.|.::.|:..:.||..:.     :.::.::...|...|.|  ..:.|.|....:.:.:.::
Human    15 LLLILLCMSLLLFQVIRLYQRR-----RWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLME 74

  Fly    67 RFGRSFMGTVLGHVVMVTA--EPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMR 129
            ::..: :...:|...|..:  :|.:...||:.|.. |....:..|..|:|.||:...|.:|...|
Human    75 KYPCA-VPLWVGPFTMFFSVHDPDYAKILLKRQDP-KSAVSHKILESWVGRGLVTLDGSKWKKHR 137

  Fly   130 KIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNVDA 194
            :|:.|.|:.|||:.|:.:......:::.:.......|..:.::..|.|..||.|.:.|.    ..
Human   138 QIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAF----SH 198

  Fly   195 QGA---DSEVVHAVKDLTNILATRFMRPHLLFPH---LFRLCWP----SGFRKQQAGVICLHEFT 249
            ||:   ||.:...:|.:.|:......|.:....|   :|:....    |.|.::      ||:||
Human   199 QGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQE------LHQFT 257

  Fly   250 NGIIEQRRRLLAREANQDKPTKPH-ALLDTLLRATVDG-QPLTDKQIRDEVNTFIFEGHDTTTSA 312
            ..:|:.|:..|..:..||...|.. ..||.||.|..:. :..::..::.||.||:|.|||||:||
Human   258 EKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSA 322

  Fly   313 VSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARC 377
            :|:.||.|:::...||:..:|:|...|..  ..:.....:.:||.:..:||.||||.|:..::|.
Human   323 ISWILYCLAKYPEHQQRCRDEIRELLGDG--SSITWEHLSQMPYTTMCIKECLRLYAPVVNISRL 385

  Fly   378 LEKDLVIDEG-YIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPR 441
            |:|.:...:| .:|.|..|.:.:|.|..:...:.||.||.|.|...|.:.::.||::||||||.|
Human   386 LDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLR 450

  Fly   442 NCIGQKFALLEMKTMVTKVIRHYQLLP-MGADVEPSIKIVLRSKSGVNV 489
            |||||.||::|.|..|...:..::|.| .....:|..::||:||:|::|
Human   451 NCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	128/428 (30%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	129/448 (29%)