Protein Alignment Cyp4ae1 and Cyp3a9

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_671739.2
• Gene: Cyp3a9 / 171352
• RGDID: 708392
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 515
• Identity: 139/515 - (26%)
• Similarity: 241/515 - (46%)
• Gaps: 66/515 - (12%)

  Fly     3 VVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAA-------WQMRSFQPDNLHDK 60
            ::|:::|::..|..:......|:|.      :|....:|.||..       |:.         ||
  Rat    13 LLLVISLVLLYLYGTHSHGIFKKLG------IPGPKPLPFLGTILAYRKGFWEF---------DK 62

  Fly    61 FAEYVKRFGRSFMGTVLG-HVVMVTAEPRHIDALLQGQHQLKKGTMYFALR------GWLGDGLL 118
            :..  |::|: ..|...| ..|:...:|..|..:|     :|:....|..|      |.|...:.
  Rat    63 YCH--KKYGK-LWGLYDGRQPVLAITDPDIIKTVL-----VKECYSTFTNRRNFGPVGILKKAIS 119

  Fly   119 LSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDII 183
            :|..:||..:|.:::|||....|::...:.::.:.:||..:|..|...:..::..:.|..::|:|
  Rat   120 ISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVI 184

  Fly   184 TETAMGVNVDA-QGADSEVVHAVKDLT--NILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICL 245
            |.|:.|||||: .......|..:|.|.  :|....|:.. .|||.|..|............||
  Rat   185 TATSFGVNVDSLNNPQDPFVEKIKKLLKFDIFDPLFLSV-TLFPFLTPLFEALNVSMFPRDVI-- 246

  Fly   246 HEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVDG-QPLTDKQIRDEVNTFIFEGHDTT 309
             :|....:|:.:....:|..:.:......::::......|. :.|:|.:|..:...|||.|::||
  Rat   247 -DFFKTSVERMKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETT 310

  Fly   310 TSAVSFCLYLLSRHEAVQQKLFEEL------RMHYGQDLFRGVILSDFATLPYLSCVVKESLRLY 368
            :||:||.||||:.|..:|:||.:|:      :.|...|        ....:.||..||.|:||||
  Rat   311 SSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYD--------TLLQMEYLDMVVNETLRLY 367

  Fly   369 PPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSY 433
            |....:.|..:.|:.|:..:||.||.|::..:.|.:|...:.:|..|:|||...:....::||.|
  Rat   368 PIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMY 432

  Fly   434 IPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKIVLRSKSGVNVGLRP 493
            :||..|||||||.:|||:.||..:.:|::::...|.   .|..|.:.| ||.|:   |:|
  Rat   433 LPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPC---KETQIPLKL-SKQGL---LQP 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	122/429 (28%)
Cyp3a9	NP_671739.2	CYP3A	67..492	CDD:410743	126/444 (28%)