DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	119/405 - (29%)
Similarity:	194/405 - (47%)	Gaps:	59/405 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 FALRGWLGDGLLLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNI 171
            |...|.|...:.||..:||..:|.:::|||....|::...:.::.:.:||:.::..:.....:.:
  Rat   108 FGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITM 172

  Fly   172 YPLVGLAALDIITETAMGVNVDA-QGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWP--- 232
            ..:.|..::|:||.|:.|||||: ....:..|..||.|   |...|:.|..|...||....|
  Rat   173 KDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKL---LKFNFLDPFFLSVILFPFLTPVFE 234

  Fly   233 ----SGFRKQQAGVICLHEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVDG-----QP 288
                :.|.|.      :.:|....:|:    :.....|:|..:....|..::.:...|     |.
  Rat   235 AFDITVFPKD------VMKFFRTSVER----MKENRMQEKVKQRLDFLQLMINSQSSGDKESHQG 289

  Fly   289 LTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFAT 353
            |||.:|..:...|||.|::||:||:||.||||:.|..:|:||.:|:.                |.
  Rat   290 LTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEID----------------AA 338

  Fly   354 LP--------------YLSCVVKESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLR 404
            ||              ||..|:.|:|||:|....:.|..:||:.|:..:||.||.|:|..:.|.:
  Rat   339 LPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGTVVMVPTFALHK 403

  Fly   405 DEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPM 469
            |...:.:|..|.|||...:....::||.|:||..|||||||.:|||:.||..:.:|::::.   .
  Rat   404 DPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFS---F 465

  Fly   470 GADVEPSIKIVLRSK 484
            |...|..|.:.||.|
  Rat   466 GLCKETQIPLKLRKK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	119/405 (29%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	119/405 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910