Protein Alignment Cyp4ae1 and CYP19A1

DIOPT Version :9

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 102/442 - (23%)
• Similarity: 190/442 - (42%)
• Gaps: 49/442 - (11%)

  Fly    58 HDKF--------AEYVKRFGRSFMGT-VLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALR--G 111
            |.:|        ..|..|....||.. :.|...::.::...:..:::..|...:......|:  |
Human    62 HGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIG 126

  Fly   112 WLGDGLLLSRGKE-WHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLV 175
            ....|::.:...| |.|.|...........|.:.|.|........::||..::..:..|::..|:
Human   127 MHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLL 191

  Fly   176 GLAALDIITETAMGVNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQA 240
            ....||......:.:.:|    :|.:|..::...:......::|.:    .|::.|.  ::|.:.
Human   192 RRVMLDTSNTLFLRIPLD----ESAIVVKIQGYFDAWQALLIKPDI----FFKISWL--YKKYEK 246

  Fly   241 GVICLHEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFE- 304
            .|..|.:....:|.::||   |.:.::|..:.......|:.|...|. ||    |:.||..|.|
Human   247 SVKDLKDAIEVLIAEKRR---RISTEEKLEECMDFATELILAEKRGD-LT----RENVNQCILEM 303

  Fly   305 ---GHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLR 366
               ..||.:.::.|.|:|:::|..|::.:.:|::...|:   |.:.:.|...|..:...:.||:|
Human   304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE---RDIKIDDIQKLKVMENFIYESMR 365

  Fly   367 LYPPIPAVARCLEKDLVIDEGYIPV--GTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLS 429
            ..|.:..|.|...:|.||| || ||  |||:::.:.::.|.| .|..|..|..|..     .:..
Human   366 YQPVVDLVMRKALEDDVID-GY-PVKKGTNIILNIGRMHRLE-FFPKPNEFTLENF-----AKNV 422

  Fly   430 PYSYI-PFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPM-GADVEPSIKI 479
            ||.|. ||..|||.|.|:..|::.||.::..::|.:.:..: |..||...||
Human   423 PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKI 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	102/442 (23%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	100/432 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154807
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030