Protein Alignment Cyp4ae1 and CYP4B1

DIOPT Version :9

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 162/513 - (31%)
• Similarity: 262/513 - (51%)
• Gaps: 46/513 - (8%)

  Fly     7 VALLVTRLVASLFRLALKELRHPLQGVVPSVSRVP------LLGAAWQMRSFQPDNLHDKFAEYV 65
            :.|..:.|:..|..|.|..|....|.:..::.:.|      |.|.|.::   |.....||...:.
Human    13 LGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEI---QETGSLDKVVSWA 74

  Fly    66 KRFGRS---FMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHT 127
            .:|..:   :.|..:|.:.:.  ||.:..| :..:...|...:|.....|:|.|||:..|.:|..
Human    75 HQFPYAHPLWFGQFIGFLNIY--EPDYAKA-VYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQ 136

  Fly   128 MRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNV 192
            .||::||.||:.:|:.:|.||...:.|::::....:...:..:|:..||..||:.:.:...|...
Human   137 HRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGD 201

  Fly   193 DAQG--ADSEVVHAVKDLTNILATRFM--RPHLLFPHLFRLCW--PSGFRKQQAGVICLHEFTNG 251
            ...|  .||....||.|||.::..|.:  :.|..|     :.|  |.|.|..:|..:. |:.|:.
Human   202 TGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDF-----IYWLTPHGRRFLRACQVA-HDHTDQ 260

  Fly   252 IIEQRRRLLAREANQDK-PTKPHA-LLDTLLRA-TVDGQPLTDKQIRDEVNTFIFEGHDTTTSAV 313
            :|.:|:..|..|..:.| ..:.|. .||.||.| ..|...|:|..:|.||:||:|||||||||.:
Human   261 VIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGI 325

  Fly   314 SFCLYLLSRHEAVQQKLFEELRMHYG-QDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARC 377
            |:.||.::.:...|.:..||:|...| ||.|:   ..|...:.||:..:|||.|||||:|.|.|.
Human   326 SWFLYCMALYPEHQHRCREEVREILGDQDFFQ---WDDLGKMTYLTMCIKESFRLYPPVPQVYRQ 387

  Fly   378 LEKDLV-IDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPR 441
            |.|.:. :|...:|.|:.:.:.::.|.|:.|::.||.||...|...|.|.:..|::::|||||||
Human   388 LSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 452

  Fly   442 NCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPS---IK---IVLRSKSGVNVGLRP 493
            |||||:||:.|||.:....:..::.     .::||   ||   :|||||:|.::.|:|
Human   453 NCIGQQFAMSEMKVVTAMCLLRFEF-----SLDPSRLPIKMPQLVLRSKNGFHLHLKP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	152/476 (32%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	153/473 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740