Protein Alignment Cyp4ae1 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 130/514 - (25%)
• Similarity: 232/514 - (45%)
• Gaps: 82/514 - (15%)

  Fly     3 VVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMR----SFQPDNLHDKFAE 63
            ::|.|:|::..|..:......|:|.      :|..:.:|.||.|...|    :|.        .|
Human    13 LLLAVSLILLYLYGTRTHGLFKKLG------IPGPTPLPFLGNALSFRKGYWTFD--------ME 63

  Fly    64 YVKRFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALR------GWLGDGLLLSRG 122
            ..|::.:.:........::...:|..|..:|     :|:....|..|      |::.:.:.::..
Human    64 CYKKYRKVWGIYDCQQPMLAITDPDMIKTVL-----VKECYSVFTNRRPFGPVGFMKNAISIAED 123

  Fly   123 KEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETA 187
            :||..:|.:::|||....|::.|.:..:...:||..||..:...:.|.:..:.|..::|:||.|:
Human   124 EEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTS 188

  Fly   188 MGVNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGI 252
            .||::|:.....:..  |::...:|....:.|.:|...:|....|            :.|..|..
Human   189 FGVSIDSLNNPQDPF--VENTKKLLRFNPLDPFVLSIKVFPFLTP------------ILEALNIT 239

  Fly   253 IEQRR--RLLAREANQD-----KPTKPHALLDTLLRATVDGQ---------PLTDKQIRDEVNTF 301
            :..|:  ..|.:...|.     |.|:.|.:  ..|:..:|.|         .|:|.::..:...|
Human   240 VFPRKVISFLTKSVKQIKEGRLKETQKHRV--DFLQLMIDSQNSKDSETHKALSDLELMAQSIIF 302

  Fly   302 IFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFA--------TLPYLS 358
            ||.|::||:|.:||.:|.|:.|..||||:.:|:          ..:|.:.|        .|.||.
Human   303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEI----------DTVLPNKAPPTYDTVLQLEYLD 357

  Fly   359 CVVKESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGE 423
            .||.|:|||:|....:.|..:||:.|:..:||.|..|::..:.|..|...:|:|..|.|||...:
Human   358 MVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

  Fly   424 EAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKIVLR 482
            ....:.||.|.||.:|||||||.:|||:.||..:.:|::::...|.   .|..|.:.||
Human   423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPC---KETQIPLKLR 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	115/437 (26%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	115/446 (26%)