DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	128/500 - (25%)
Similarity:	206/500 - (41%)	Gaps:	68/500 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LVVLLVALLVTRLVASLFRLALKEL----------RHPLQGVVPSVSRVPLLGAAWQMRSFQPDN 56
            |..||.:.|.|.::..|..||..:|          |.....:.|.....|..|...|| ..|
  Rat     3 LPALLASALCTFVLPLLLFLAALKLWDLYCVSSRDRSCALPLPPGTMGFPFFGETLQM-VLQ--- 63

  Fly    57 LHDKFAEYVKR-FGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLS 120
             ..||.:..:| :|..:...:.|...:......::..:|.|:|:|.......::|..||.|.|.:
  Rat    64 -RRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGAGCLSN 127

  Fly   121 RGKEWHTMR-KIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIIT 184
            .....|..| |:|...|:...|:.:|.|...:.|..:|  :.||.|...:.:||.|......|..
  Rat   128 LHDSSHKQRKKVIMQAFNREALQCYVPVIAEEVSGCLE--QWLSCGERGLLVYPEVKRLMFRIAM 190

  Fly   185 ETAMGVNVDAQGA---DSEVVHAVKDLTNILATRFMRP-HLLFPHLFRLCWPSGFRKQQAGVICL 245
            ...:|......|.   :.::|.|.:::|..|   |..| .:.|..|:|     |.:.:.    .:
  Rat   191 RILLGCEPGPAGGGEDEQQLVEAFEEMTRNL---FSLPIDVPFSGLYR-----GVKARN----LI 243

  Fly   246 H-EFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVD-----GQPLTDKQIRDEVNTFIFE 304
            | .....|..:.|||.|.|        |.|.....|:..::     |:.|..:.::......:|.
  Rat   244 HARIEENIRAKIRRLQAAE--------PDAGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300

  Fly   305 GHDTTTSAVSFCLYLLSRHEAVQQKLFEEL-------RMHYGQDLFRGVILSDFAT---LPYLSC 359
            ||:||.||.:..:..|..:..|.||:.||:       :.|:...|       |..|   |.|:.|
  Rat   301 GHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSHHEDKL-------DMETLEQLKYIGC 358

  Fly   360 VVKESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEE 424
            |:||:|||.||:|...|...|...::...||.|.||:..:.........||:...|.|:|.....
  Rat   359 VIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADSFTNKEEFNPDRFTSLH 423

  Fly   425 APRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRH--YQLL 467
            ....|.:|:|||..|.|:|:|::||.:.:|....::.|.  :|||
  Rat   424 PEDTSRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARRCDWQLL 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	117/456 (26%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	117/459 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000