DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	488	Identity:	145/488 - (29%)
Similarity:	250/488 - (51%)	Gaps:	21/488 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFRLALKELRHPL--QGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAEYVKRFGRSFMGTVLG- 78
            |||.:..|.::..|  |.::.::...|.:.:.|.......|....:...:|::|..:.:..:.|
Mouse    26 SLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGHHLKDKELQQILIWVEKFPSACLQCLSGS 90

  Fly    79 HVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMRKIITPTFHFSILEQ 143
            ::.::..:|.::..:| |:...|...:|.....|:|.||||..||:|...|:::||.||:.||:.
Mouse    91 NIRVLLYDPDYVKVVL-GRSDPKASGIYQFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKP 154

  Fly   144 FVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNVDAQGADSEVVH--AVK 206
            :|::.....:|::::...|...:..:.|:..|.|..||.:.:.|.......|..::..::  ||:
Mouse   155 YVKIMADSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENSKLYTKAVE 219

  Fly   207 DLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQRRRLLAREANQDKPTK 271
            ||.|:...|.......:..::.:  .|..|.........||.|:|:|:.|:..|..|....|..|
Mouse   220 DLNNLTFFRLRNAFYKYNIIYNM--SSDGRLSHHACQIAHEHTDGVIKMRKSQLQNEEELQKARK 282

  Fly   272 PHAL--LDTLLRATV-DGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEE 333
            ...|  ||.||.|.: |...|:|:.:|.||:||:|||||||.|.:|:..|.|:.|...||:..||
Mouse   283 KRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREE 347

  Fly   334 LRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEG-YIPVGTNVVV 397
            ::...|..  ..|.......:||.:..:||:||||||:.:|:|.|...:...:| .||.|....:
Mouse   348 VQSILGDG--TSVTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPKGITATI 410

  Fly   398 LLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYS--YIPFSAGPRNCIGQKFALLEMKTMVTKV 460
            .::.|..:...:.:|.||.|.|.    ||..|.:|  |:|||.|.|||||::||:.|:|..|...
Mouse   411 SIYGLHHNPRFWPNPKVFDPSRF----APDSSHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALT 471

  Fly   461 IRHYQLLPMGADVE-PSIKIVLRSKSGVNVGLR 492
            :..::|||....:. |..::||:||:|:::.|:
Mouse   472 LLRFELLPDPTRIPVPIARLVLKSKNGIHLCLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	137/460 (30%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	138/457 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740