DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	476	Identity:	144/476 - (30%)
Similarity:	241/476 - (50%)	Gaps:	42/476 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 WQMRSFQ-----PDNL---HDKF-------------AEYVKRFGRSFMGTVLGHVVMVTAEPRHI 90
            |.:::||     |.:.   |:||             ..:...|.|.|.|:   ...:...:|.::
Mouse    43 WLLKAFQQFPSPPFHWFFGHEKFKGDQELQEIVSCIENFPSAFPRWFWGS---KAYLTVYDPDYM 104

  Fly    91 DALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSIL 155
            ..:| |:...|....|..|..|:|.||||..|:.|...|:::||.||:.||:.:|:.......::
Mouse   105 KVIL-GRSDPKANGAYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLM 168

  Fly   156 VERLRTLSYGNEVVNIYPLVGLAALDIITETAM----GVNVDAQGADSEVVHAVKDLTNILATRF 216
            :::...|:..:..:.|:..:.|..||.:.:.|.    .|.||  |.....:.|:.||.|:..:|.
Mouse   169 LDKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVD--GNYRTYLQAIGDLNNLFHSRV 231

  Fly   217 MRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQRRRLLAREANQDKPTKPHAL--LDTL 279
            .........:::|.......||...:  .|:.|:|:|:.|:..|..|...:|..|...|  ||.|
Mouse   232 RNIFHQNDTIYKLSSNGRLAKQACQL--AHDHTDGVIKLRKDQLQDEGELEKIKKKRRLDFLDIL 294

  Fly   280 LRATVD-GQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLF 343
            |.|.:: |..::||.:|.||:||:|||||||.|.||:..|.|:.|...||:..||::...|..
Mouse   295 LFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDG-- 357

  Fly   344 RGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEG-YIPVGTNVVVLLWQLLRDEA 407
            ..:.......:||.:..:||:||||||:|.:.|.|...:...:| .:|.|..|.:.::.|..:..
Mouse   358 SSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPK 422

  Fly   408 IFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGAD 472
            ::.:|.||.|.| ...::||.| :|::|||.|.|||||::||:.|:|.:|...:..::|||....
Mouse   423 VWPNPEVFDPSR-FAPDSPRHS-HSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTR 485

  Fly   473 VE-PSIKIVLRSKSGVNVGLR 492
            |. |..::||:||:|:.:.|:
Mouse   486 VPMPLARLVLKSKNGIYLHLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	142/468 (30%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	140/462 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740