DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ae1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	514	Identity:	190/514 - (36%)
Similarity:	288/514 - (56%)	Gaps:	41/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VALLVTRLVASLFRLALKELRHPLQ-GVVPSVSRV-PLLGAAWQMRSFQPDN--LHDKFAEYVKR 67
            |:|....::.|:|.:.:...|...| ..:|||:|. ||:|.|..|:   |:|  ...:...|.:.
Mouse    22 VSLAGATILISIFPMLVSYARKWQQMRSIPSVARAYPLVGHALYMK---PNNAEFFQQLIYYTEE 83

  Fly    68 FGR-SFMGTVLGHVVMVTA-EPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMRK 130
            |.. ..:...:|.|.:|.. :..:::.:|....|:.|..:|..|:.|||.|||.|.|.:|.|.||
Mouse    84 FRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRK 148

  Fly   131 IITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNVDAQ 195
            ::||||||:|||.|::|.:.|::|||.:|.. ....|..|.:..:.|.|||||.|||||.|:.||
Mouse   149 MLTPTFHFTILENFLDVMNEQANILVNKLEK-HVNQEAFNCFFYITLCALDIICETAMGKNIGAQ 212

  Fly   196 -GADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQRRRL 259
             ..|||.|..|..:::::..|...|.|.| .|:.|.:..| |..:.|:.|||.|||.:|.:  |:
Mouse   213 SNNDSEYVRTVYRMSDMIYRRMKMPWLWF-DLWYLVFKEG-RDHKRGLKCLHTFTNNVIAE--RV 273

  Fly   260 LAREANQD----------KPTKPHALLDTLLRAT-VDGQPLTDKQIRDEVNTFIFEGHDTTTSAV 313
            ..|:|.:|          ...|..|.||.||..| .:|..|:.:.||:||:||:|||||||.:|:
Mouse   274 KERKAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTTAAAI 338

  Fly   314 SFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCL 378
            ::.||||..:..||:|:.:||...:|:. .|.|.|.|...|.||.||:||:||::|.:|..||.|
Mouse   339 NWSLYLLGTNPEVQRKVDQELDEVFGRS-HRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSL 402

  Fly   379 EKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRNC 443
            .:|..:....:..||..:::.:.|.||...|.||..|:|||...|.:....||:|:|||||||||
Mouse   403 SEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQGRHPYAYVPFSAGPRNC 467

  Fly   444 IGQKFALLEMKTMVTKVIRHY--------QLLPMGADVEPSIKIVLRSKSGVNVGLRPR 494
            ||||||::|.||::..::|.:        :.|.:..|      ::||..:|:.:.|:.|
Mouse   468 IGQKFAVMEEKTILACILRQFWVESNQKREELGLAGD------LILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	181/475 (38%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	182/480 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844927
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850