Protein Alignment Cyp4ae1 and cyp46a1.4

DIOPT Version :10

• Sequence 1: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_002933245.2
• Gene: cyp46a1.4 / 100498621
• XenbaseID: XB-GENE-29072485
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 507
• Identity: 139/507 - (27%)
• Similarity: 245/507 - (48%)
• Gaps: 44/507 - (8%)

  Fly     9 LLVTRLVASLFRLALKELRHPLQGVVPSVSR-------VPLLGAAWQMRSFQPDNLHDKFAEYVK 66
            :::..:||.|...|..:..|.....:|...|       :|.|..|.:..|.    :||.|..:.:
 Frog    20 IIIGAVVAFLAYCAYIKYMHLKYDDIPGPPRDSFLLGHIPTLSKAEENYSV----VHDLFLHWAE 80

  Fly    67 RFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMY---FALRG--WLGDGLLLSRGKE-W 125
            .:|..|...:|..|::.:..|..:...|......|....|   |.|.|  :||.|||.....: |
 Frog    81 IYGPVFKINILHRVMIYSTSPESVKECLMSSKYPKDPYTYNQLFNLFGKRFLGKGLLTDPDHDHW 145

  Fly   126 HTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGV 190
            :..|:|:.|.|..:.|::.:.:|:.::..::|:|...:.|::.|:::.::....||:||:.|.|:
 Frog   146 YHQRRIMDPAFSNTYLKEMIGIFNERAEQMMEKLEEKADGHQEVSMHSIINRVTLDVITKVAFGM 210

  Fly   191 NVD-AQGADSEVVHAV-KDLTNILATRFMR-PHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGI 252
            ::. .:|..::..:|: |.||.::  |:|: |::.:   |...| :..|:.|.....|.:.....
 Frog   211 DLGLVEGNKTDFPNAISKVLTGMM--RYMQNPYMQY---FPKHW-AFVREVQESADLLRKTGKEC 269

  Fly   253 IEQRRRLLAREANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCL 317
            |.||::     |.|:....|..:|..:|:.......|.|:.:.|...||...|.:||.:.:||.:
 Frog   270 ISQRKK-----AMQNGEELPKDILTKILQCAELENALDDEIMLDNFITFFIAGQETTANQLSFTV 329

  Fly   318 YLLSRHEAVQQKLFEELRMHYGQ--DLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEK 380
            ..|:|    |.::..:|||...:  ...|.:...|...|.|::.|:|||||.|||.|..:|.|::
 Frog   330 MELTR----QPEIMTKLRMEVDEVIGFKRDISYDDIQNLNYMTQVLKESLRFYPPGPGTSRYLKE 390

  Fly   381 DLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPY-SYIPFSAGPRNCI 444
            |.:.:...||.|.::....:.:.|.|..|.||..|.|||.   ....:.|| .|.||:.|||:|:
 Frog   391 DTIFEGIKIPGGVSITFNTYVMGRMEKFFQDPCKFDPERF---HPAAVKPYFCYFPFALGPRSCL 452

  Fly   445 GQKFALLEMKTMVTKVIR--HYQLLPMGADVEPSIKIVLRSKSGVNVGLRPR 494
            ||.|:.||.|.:::|:|:  .::|:| |..........||.:.||...|:.|
 Frog   453 GQIFSQLEAKVILSKLIQRFEFELVP-GQSFGIKDTGTLRPRDGVVCTLKSR 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	121/426 (28%)
cyp46a1.4	XP_002933245.2	CYP46A1-like	72..498	CDD:410706	126/444 (28%)