Protein Alignment Cyp4d2 and ERG11

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 538
• Identity: 115/538 - (21%)
• Similarity: 224/538 - (41%)
• Gaps: 117/538 - (21%)

  Fly     5 VGVLLLVAFATLLLWDFLWRRRGNGILPGPRP------LPFLGNLLMYRGLDPEQIMDFVKKNQR 63
            :.:::::.|...::|..|:..|.:      ||      :|::|:.::| |:.|   .:|.::.|:
Yeast    31 ISLIIIIPFIYNIVWQLLYSLRKD------RPPLVFYWIPWVGSAVVY-GMKP---YEFFEECQK 85

  Fly    64 KYGRLYRVWILHQLAVFSTDPRDIEFVLSSQ----------QHIT-----KNNLYKLLNCWLGDG 113
            |||.::...:|.::......|:..|||.:::          .|:|     |..:|...|..|.:.
Yeast    86 KYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQ 150

  Fly   114 LLMSTGRKWHGRRKIITPTFHFKILEQFVEIF-DQQSAVMVEQLQSRADGMT---PINIFPVICL 174
            .....|.......|...|.    |.|:..:.| |.::..:.|:.....|.|.   .:.||
Yeast   151 KKFVKGALTKEAFKSYVPL----IAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIF----- 206

  Fly   175 TALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKA 239
            ||    :.:.:|.::.|:.:.:..|:.:..|          ..:..::::|........:::|.|
Yeast   207 TA----SRSLLGKEMRAKLDTDFAYLYSDLD----------KGFTPINFVFPNLPLEHYRKRDHA 257

  Fly   240 IKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTI--DGAPLSDEDIR 302
            .|.:.....::|:|||:   ||..:...              |:|.|::::.  ||..::|::|.
Yeast   258 QKAISGTYMSLIKERRK---NNDIQDRD--------------LIDSLMKNSTYKDGVKMTDQEIA 305

  Fly   303 EEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENV 367
            ..:...:..|..|:.:..::.|..::..|:|||.|.:|...|| :..|..:|...|.|:..:...
Yeast   306 NLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVL-DGGKKELTYDLLQEMPLLNQT 369

  Fly   368 IKESLRLHPPVPMIGRWFAEDVEIRGKH--IPAGTNFTMGI-FVLLRDPEYFESPDEFRPERFDA 429
            |||:||:|.|:..:.|...:|:.:....  ||||.:..:.. :..||| |||.:..:|...|::.
Yeast   370 IKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRD-EYFPNAHQFNIHRWNK 433

  Fly   430 DVPQIHPYA-----------------YIPFSAGPRNCIGQKFAMLEMKSTVSKLLR----HFE-- 471
            |....:...                 |:||..|...|||:.||..::...:|..:|    |:.
Yeast   434 DSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEG 498

  Fly   472 ------------LLPLGP 477
                        .||.||
Yeast   499 KTVPPPDFTSMVTLPTGP 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	100/471 (21%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	103/476 (22%)