Protein Alignment Cyp4d2 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 183/512 - (35%)
• Similarity: 283/512 - (55%)
• Gaps: 33/512 - (6%)

  Fly     7 VLLLVAFATLLLWDFLWR-------RRGNGILPGPRPLPFLGNLLMYRGLDP-EQIMDFVKKNQR 63
            :||||..:.||.....|.       ||.......||...|.|:..|   ::| |:.|..:.:...
Human    21 LLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGM---VNPTEEGMRVLTQLVA 82

  Fly    64 KYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNN--LYKLLNCWLGDGLLMSTGRKWHGR 125
            .|.:.::||:.....:.| ..|..|..|:::...|...:  .|..|..|||||||:|.|.||...
Human    83 TYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRH 147

  Fly   126 RKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRA-DGMTPINIFPVICLTALDIIAETAMGTKI 189
            |:::||.|||.||:.:::||::...:|..:.|..| :|...:::|..|.|..||.:.:.......
Human   148 RRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDS 212

  Fly   190 NAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRER 254
            :.|:.|: .|:.|:.:::.::.||.......:|:::.||  .:.:|..:|.:::||||:.:|:||
Human   213 HCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLT--PDGQRFRRACRLVHDFTDAVIQER 274

  Fly   255 RETLVNNSKETTPEEEV-NFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMFEGHD 314
            |.||        |.:.| :||..|.:...||    :||....||..|||||||.|.|||||||||
Human   275 RRTL--------PSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHD 331

  Fly   315 TTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVP 379
            ||.|.:|:.||.:::|||.|:|.:||::::|.:.....:...||..|.|:...:|||||||||||
Human   332 TTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVP 396

  Fly   380 MIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHPYAYIPF 442
            :|.|...:|:.: .|:.||.|....:.:|....:|..:..|:.:.|.|||.: :.:..|.|:|||
Human   397 VISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPF 461

  Fly   443 SAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            ||||||||||.|||.|||..::..|..|.:||...|||....:|||:..|:.|.::|
Human   462 SAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	163/439 (37%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	165/451 (37%)