DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and DIT2

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_010690.1	Gene:	DIT2 / 852011	SGDID:	S000002810	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	121/522 - (23%)
Similarity:	217/522 - (41%)	Gaps:	105/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGN----------LLMYRGLDPEQIMD-FVKK 60
            :|.|:.|.||....|..      |:|   ||.|..|          |.:...:|..::.| ::::
Yeast     6 LLCLILFLTLSYVAFAI------IVP---PLNFPKNIPTIPFYVVFLPVIFPIDQTELYDLYIRE 61

  Fly    61 NQRKYGRL-------YRVWILHQ--LAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLM 116
            :..|||.:       :.:.:...  ||....|  :..|..|..|   |...|..|..:.||.::.
Yeast    62 SMEKYGAVKFFFGSRWNILVSRSEYLAQIFKD--EDTFAKSGNQ---KKIPYSALAAYTGDNVIS 121

  Fly   117 STGRKWHGRRKIITPTF-HFKILEQFVEIFDQQSAVMVEQLQSR-ADGMTPINIFPVICLTALDI 179
            :.|..|...|..:|... ||.....|     :.:.::...:::| .:|.|.|.:.|:....|||.
Yeast   122 AYGAVWRNYRNAVTNGLQHFDDAPIF-----KNAKILCTLIKNRLLEGQTSIPMGPLSQRMALDN 181

  Fly   180 IAETAMGTKINA---QKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQP----TEAKRQD 237
            |::.|:|....|   :||       |.::....:.|:..|.       |.||.|    .....:.
Yeast   182 ISQVALGFDFGALTHEKN-------AFHEHLIRIKKQIFHP-------FFLTFPFLDVLPIPSRK 232

  Fly   238 KAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIR 302
            ||.|.:..|.|.:::..::.||||.|    .|:..|....    |:.......||...|:|
Yeast   233 KAFKDVVSFRELLVKRVQDELVNNYK----FEQTTFAASD----LIRAHNNEIIDYKQLTD---- 285

  Fly   303 EEVDTFMFEGHDTTTSAISFCLYEISRHP-EVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMEN 366
             .:...:..||:......:..||.::::. |.|::|::|:..:  .|.|.      |.:|..:..
Yeast   286 -NIVIILVAGHENPQLLFNSSLYLLAKYSNEWQEKLRKEVNGI--TDPKG------LADLPLLNA 341

  Fly   367 VIKESLRLHPPV-PMIGRWFAEDVEIRGK-HIPAGTNFTMGIFVLLRDPE-YFESPDEFRPERFD 428
            .:.|.:|::||: .:|.|...:..::..: .||.|.......|....||: :..:.|:|:|||:.
Yeast   342 FLFEVVRMYPPLSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADDFKPERWG 406

  Fly   429 ADVPQI--------HPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHF----------ELLPL 475
            :|:..|        :..|...|..|.|.|:|:|.|:.||:.:::::|:.|          :|.|.
Yeast   407 SDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEKLTPA 471

  Fly   476 GP 477
            ||
Yeast   472 GP 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	114/497 (23%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	106/454 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900