DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	513	Identity:	181/513 - (35%)
Similarity:	285/513 - (55%)	Gaps:	31/513 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLP----FLGNLLMYRGLDPEQIMDFVKKN 61
            :|||...:|    |.:|.|.:.:....:.:...|:| |    |.|:|.|.:  ..|:.|..|.:.
Mouse    23 LLGVASWIL----ARILAWTYSFYENCSRLSCFPQP-PKKNWFSGHLGMIQ--SNEEGMQLVTEM 80

  Fly    62 QRKYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNNL--YKLLNCWLGDGLLMSTGRKWH 123
            .:.:..::..|:...:.|.. .||..:..:|.:...:...::  .:.|..||||||.:|:|.||.
Mouse    81 GQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGLFLSSGDKWS 145

  Fly   124 GRRKIITPTFHFKILEQFVEIFDQQSAVM-VEQLQSRADGMTPINIFPVICLTALDIIAETAMGT 187
            ..|:::||.|||.||:.:|:||:|...:| .:.....::|...:.:|..|.|..||.:.:...|.
Mouse   146 RHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGF 210

  Fly   188 KINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIR 252
            ..|.|::|: .|:.|:.::::::|||.:..:..||:::..|  .:.:|..||..::|:||:.:||
Mouse   211 DSNCQESPS-EYISAILELSSLIIKRSLQLFLFVDFLYYHT--ADGRRFRKACDLVHNFTDAVIR 272

  Fly   253 ERRETLVNNSKETTPEEEVNFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMFEGH 313
            |||.||.:.:.:       .||..|.:...||    :||.....|..|||||||.|.|||||.||
Mouse   273 ERRHTLSSQNHD-------EFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGH 330

  Fly   314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPV 378
            |||.||:|:.||.::||||.|:|.:||::::|.:.....:...||.:|.|:...||||||||.||
Mouse   331 DTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHSPV 395

  Fly   379 PMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIH-PYAYIP 441
            ..:.|....|:.: .|:.||.|....:.||.:..:|..:..|:.:.|.|||.:.||.. |.|:||
Mouse   396 IDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENPQKRSPLAFIP 460

  Fly   442 FSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            |||||||||||.|||.|||..::..|..|.:||...|||....|:||:..|:.|.::|
Mouse   461 FSAGPRNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	172/476 (36%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	172/474 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640