DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	168/505 - (33%)
Similarity:	270/505 - (53%)	Gaps:	21/505 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLWDFLWRRRGNGI--LP-GPRPLPFLGNLLMYRGLDPEQIMDFVKKNQ 62
            :||....:|    |.:|.|.:.:....:.:  .| .|:...|||:|.:.:  ..|:.|..|.:..
  Rat    23 LLGAASWIL----ARILAWTYSFCENCSRLRCFPQSPKRNWFLGHLGVIQ--SNEEGMQLVTEMG 81

  Fly    63 RKYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNN--LYKLLNCWLGDGLLMSTGRKWHG 124
            :.:..::.:|:.....|.. .||..:..:|.:...:...:  ....|..||||||.:|:|.||..
  Rat    82 QTFRDVHLIWLGPVSPVLRLVDPAFVAPLLQAPALVAPKDPTFLHFLKPWLGDGLFLSSGDKWSR 146

  Fly   125 RRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRA-DGMTPINIFPVICLTALDIIAETAMGTK 188
            .|:::||.|||.||:.:|:.|:|...:|..:.:... :|...:.:|..|.|..||.:.:...|..
  Rat   147 HRRLLTPAFHFDILKPYVKTFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLFGFD 211

  Fly   189 INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRE 253
            .|.|::|: .|:.|..:::::..||....:..:|:::..|  .:.:|..||..::|.||:.:|||
  Rat   212 SNCQESPS-EYISATLELSSLTRKRSYKLFLYLDFLYYRT--ADGQRFRKACDLVHSFTDAVIRE 273

  Fly   254 RRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFEGHDTTT 317
            ||..|.:...:...|.:..  .:.:.:..:||||.:..: |..|||||||.|.|||||.|||||.
  Rat   274 RRRLLSSQGVDEFLESKTK--SKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTA 336

  Fly   318 SAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIG 382
            ||:|:.||.::.|||.|:|.:||:.::|.:.....:...||.:|.|:...||||||||||...:.
  Rat   337 SALSWILYNLASHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPAVDLL 401

  Fly   383 RWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIH-PYAYIPFSAG 445
            |...:|:.: .|:.||.|....:.||.:..:|..:..|:.:.|.|||.:..|.. |.::||||||
  Rat   402 RRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENRQKRSPLSFIPFSAG 466

  Fly   446 PRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHL 495
            |||||||.|||.|:|..|...|..|..||...|||....::||:..|:.|
  Rat   467 PRNCIGQTFAMNEVKVAVGLTLLRFRFLPDDKEPRRKPELILRAEGGLWL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	161/470 (34%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	155/448 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750