DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	515	Identity:	178/515 - (34%)
Similarity:	280/515 - (54%)	Gaps:	35/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLP----FLGNLLMYRGLDPEQIMDFVKKN 61
            :||....:|    |.:|.|.:.:....:.:...|:| |    |||:|.|..  ..|:.|..:.:.
Mouse    23 LLGAASWIL----ARILAWTYSFCENCSRLRCFPQP-PKRNWFLGHLGMIE--HNEEGMQLMTEA 80

  Fly    62 QRKYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNN--LYKLLNCWLGDGLLMSTGRKWH 123
            .:.|..::..|:...:.|.. .||..:..:|.:...:...:  .:..:..||||||.:::|.||.
Mouse    81 GQTYRDVHLCWLGPVIPVLRIVDPAFVAPLLLASALVAPKDTTFHTFVKPWLGDGLFLNSGDKWS 145

  Fly   124 GRRKIITPTFHFKILEQFVEIFDQQSAVM-VEQLQSRADGMTPINIFPVICLTALDIIAETAMGT 187
            ..|:::||.|||.||:.:|:||:|...:| .:.....::|...:.:|..|.|..||.:.:...|.
Mouse   146 RHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGF 210

  Fly   188 KINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIR 252
            ..|.|::|: .|:.|:.::::::|||....:..||:::..|  .:.:|..||..::|:||:.:||
Mouse   211 DSNCQESPS-EYISAILELSSLVIKRSHQLFLFVDFLYYHT--ADGRRFRKACDLVHNFTDAVIR 272

  Fly   253 ERRETLVNNSKETTPEEEVNFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMFEGH 313
            |||.||.:.:.:       .||..|.:...||    :||.....|..|||||||.|.|||||.||
Mouse   273 ERRHTLSSQNHD-------EFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGH 330

  Fly   314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPV 378
            |||.||:|:.||.::||||.|:|.:||::::|.......:...||.:|.|:...|||||||||||
Mouse   331 DTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDDLAQLPFLTMCIKESLRLHPPV 395

  Fly   379 PMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIH---PYAY 439
            ..:.|....|:.: .|:.||.|....:.||.:..:|..:..|:.:.|.|||.:  ..|   |.|:
Mouse   396 IDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPE--NAHKRPPLAF 458

  Fly   440 IPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            |||||||||||||.|||.||...::..|..|.:||...|||....|:||:..|:.|.::|
Mouse   459 IPFSAGPRNCIGQTFAMNEMMVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	170/478 (36%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	161/452 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.640